Flavivirus

Flavivirus is a group of single-stranded positive-sense RNA viruses that are mainly transmitted by arthropods such as mosquitoes and ticks. The viral particles of the Flavivirus are spherical, with a diameter of approximately 40-60 nanometers and have an envelope. The envelope is embedded with spike glycoproteins, which play a crucial role in the recognition and binding process between the virus and host cells. Flavivirus contains a variety of viruses, such as the yellow fever virus and the dengue virus, etc., which can cause a variety of serious diseases and have a significant impact on global public health security^[1].

References:

[1]. Chong HY, et al. Flavivirus infection-A review of immunopathogenesis, immunological response, and immunodiagnosis. Virus Res. 2019 Dec;274:197770. [Content Brief]

Flavivirus Inhibitors (72)

Flavivirus Related Products (148)
Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P990825

Anti-Chikungunya virus E2 Antibody (CHK-265)	Inhibitor
Anti-Chikungunya virus E2 Antibody (CHK-265) is a kind of mouse IgG2c in vivo mouse antibody, targeting to B domain of the E2 glycoprotein of chikungunya virus. The recommend isotype control of Anti-Chikungunya virus E2 Antibody (CHK-265): Mouse IgG2c kappa, Isotype Control (HY-P99981).

HY-124082R

Dodecyl gallate (Standard)	Inhibitor
Dodecyl gallate (Standard) is the analytical standard of Dodecyl gallate. This product is intended for research and analytical applications. Dodecyl gallate (Lauryl gallate) has been widely used as an antioxidant in food manufacturing, as well as in the pharmaceutical and cosmetic industries. Dodecyl gallate also is active against a highly relevant animal virus such as African swine fever virus (ASFV).

HY-A0018

Palonosetron	Inhibitor
Palonosetron is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. Palonosetron exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron also possesses antidepressant activity.

HY-B0190B

Nafamostat hydrochloride
Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall.

HY-124618

FGI-106
FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC₅₀s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC₅₀s of 200 nM and 150 nM, respectively.

HY-B0433B

Quinine hemisulfate
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

HY-150600

NS2B/NS3-IN-7	Inhibitor
NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a K_i value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.

HY-155053

ZIKV-IN-6	Inhibitor
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC₅₀＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis.

HY-B0421S2

Mycophenolic acid-¹³C₁₇	Inhibitor
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-152083

DENV-IN-9
DENV-IN-9 (Compound 5f) is a DENV2 inhibitor with an EC₅₀ of 0.88 μM.

HY-146193

Zika virus-IN-3	Inhibitor
Zika virus-IN-3 (Compd 7) is a Zika virus inhibitor, with an EC₅₀ of 3.4 μM .

HY-10396A

(2R,3S)-Emricasan	Inhibitor
(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan (HY-10396). Emricasan is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.

HY-W010668R

Quinine sulfate hydrate (Standard)
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.

HY-146417

Antiviral agent 19
Antiviral agent 19 (Compound 3) is a selective inhibitor against Zika virus infection with an EC₅₀ of 1.3 µM. Antiviral agent 19 has low cytotoxicity.

HY-161642

DENV-2/ZIKV-IN-1	Inhibitor
DENV-2/ZIKV-IN-1 (Compd 16a) is a dual inhibitor of Dengue virus (DENV) and Zika virus (ZIKV) with EC₅₀s of 1.4 and 2.4 μM, respectively.

HY-A0021S

Palonosetron-d₃ hydrochloride	Inhibitor
Palonosetron-d₃ hydrochloride is the deuterium labeled Palonosetron hydrochloride (HY-A0021). Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity.

HY-152081

DENV-IN-7
DENV-IN-7, a flavone analog, is a dengue virus (DENV) inhibitor with an EC₅₀ value of 70 nM. DENV-IN-7 has low toxicity against normal cell and anti-dengue activity.

HY-15503

PHA-690509	Inhibitor
PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity.

HY-N2076

Cephaeline hydrochloride	Inhibitor
Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

HY-146957

ZIKV-IN-1	Inhibitor
ZIKV-IN-1 is a potent zika virus inhibitor with an EC₅₀ of 2.8 μM and EC₉₀ of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Flavivirus

Flavivirus Related Products (148)

Antibodies (2)

Flavivirus Related Products (148):