Flavivirus

Flavivirus is a group of single-stranded positive-sense RNA viruses that are mainly transmitted by arthropods such as mosquitoes and ticks. The viral particles of the Flavivirus are spherical, with a diameter of approximately 40-60 nanometers and have an envelope. The envelope is embedded with spike glycoproteins, which play a crucial role in the recognition and binding process between the virus and host cells. Flavivirus contains a variety of viruses, such as the yellow fever virus and the dengue virus, etc., which can cause a variety of serious diseases and have a significant impact on global public health security^[1].

References:

[1]. Chong HY, et al. Flavivirus infection-A review of immunopathogenesis, immunological response, and immunodiagnosis. Virus Res. 2019 Dec;274:197770. [Content Brief]

Flavivirus Inhibitors (64)

Flavivirus Related Products (138)
Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-100749

HeE1-2Tyr
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC₅₀ of 27.6 μM) activity in vitro.

HY-139602C

(-)-JNJ-A07	Inhibitor	99.75%
(-)-JNJ-A07 is a potent and selective DENV inhibitor with an EC₅₀ value of 31 nM.

HY-126113

KIN101		99.44%
KIN101 is a potent RNA viral inhibitor with IC₅₀s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.

HY-N0100S

Naringenin-d₄		99.88%
Naringenin-d₄ is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity.

HY-N0838

Cephalotaxine		99.21%
Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity.

HY-144612

NS2B/NS3-IN-2		98.10%
NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC₅₀ of 6.0 nM and K_i of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate.

HY-100528A

Dianemycin	Inhibitor	99.67%
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

HY-144644

NS2B/NS3-IN-3	Inhibitor	98.98%
NS2B/NS3-IN-3 (Compd 66) is an inhibitor of Flavivirus NS2B-NS3 protease.

HY-144644A

NS2B/NS3-IN-3 hydrochloride	Inhibitor	98.00%
NS2B/NS3-IN-3 hydrochlorideis an inhibitor of Flavivirus NS2B-NS3 protease.

HY-N7121

Erythromycin estolate	Inhibitor	98.98%
Erythromycin estolate is the Erythromycin (HY-B0220) derivative, is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport.

HY-W011100

Cyclofenil	Inhibitor
Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC₅₀ of 1.62 μM. Cyclofenil has anti-dengue-virus activity.

HY-16134A

Celgosivir hydrochloride		≥98.0%
Celgosivir hydrochloride (MBI 3253 hydrochloride; MDL 28574 hydrochloride; MX3253 hydrochloride) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC₅₀ of 1.27 μM in in vitro assay.

HY-134665

NITD-2		99.36%
NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly.

HY-124645

QL-X-138		99.77%
QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC₅₀s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC₅₀ of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies.

HY-144645

SP-471P		99.46%
SP-471P is a potent dengue virus (DENV) protease inhibitor with EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC₅₀ value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.

HY-U00160

SP187		99.30%
SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.

HY-117430

Hymeglusin		99.30%
Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC₅₀ = 0.12 μM). Hymeglusin covalently modifies the active Cys¹²⁹ residue of the enzyme.

HY-114621

DB772	Inhibitor	99.50%
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity.

HY-112254

ZINC03129319		98.50%
ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (K_i1) of 92 μM and K_i3 of 20 μM.

HY-124662

IHVR-19029		≥98.0%
IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC₅₀ of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir (HY-14768) improves the antiviral efficacy.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Flavivirus

Flavivirus Related Products (138)

Antibodies (2)

Flavivirus Related Products (138):