2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Endonuclease

Endonuclease

Endonuclease

Endonucleases are a class of enzymes that can cleave phosphodiester bonds within nucleic acid molecules. According to the substrates they act on, endonucleases can be classified into DNA endonucleases and RNA endonucleases. According to their structural and functional characteristics, endonucleases can be divided into restriction endonucleases, non-specific endonucleases, and site-specific endonucleases. Endonucleases play an important role in the fields of DNA repair, RNA processing, and genetic engineering. Mutations in the genes encoding endonucleases can lead to genetic diseases, such as xeroderma pigmentosum. Abnormal expression or altered activity of endonucleases may promote tumorigenesis, be involved in the pathological processes of neurodegenerative diseases, and at the same time, endonucleases are also potential targets for the treatment of diseases such as tumors[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146125
    CGCG/CGG ligand 1
    		Inhibitor
    CGCG/CGG ligand 1 (compound 10), an anthracenone derivative, is a CGCG or CGG short spacer-ligand. CGCG/CGG ligand 1 can protect cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme.
    CGCG/CGG ligand 1
  • HY-E70603
    T4 endonuclease VII
    T4 endonuclease VII displays broad substrate specificity and can bind and cleave single-base mismatches in a DNA duplex as well as three-way and four-way branched DNA structures.
    T4 endonuclease VII
  • HY-174431
    PAN endonuclease-IN-3
    		Inhibitor
    PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC50 of 17.4 nM. PAN endonuclease-IN-3 demonstrates potent inhibitory activities against PAN endonuclease. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model.
    PAN endonuclease-IN-3
Cat. No. Product Name / Synonyms Application Reactivity