2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dihydrofolate reductase (DHFR)
  5. Dihydrofolate reductase (DHFR) Agonist

Dihydrofolate reductase (DHFR) Agonist

Dihydrofolate reductase (DHFR) Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-117000A
    D156844 hydrochloride
    		Agonist
    D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research.