2. Signaling Pathways
  3. Cytoskeleton
  4. Claudin
  5. Claudin Inhibitor

Claudin Inhibitor

Claudin Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-N2468
    Xylobiose
    		Inhibitor ≥98.0%
    Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome.
  • HY-W014507
    9,10-Phenanthrenequinone
    		Inhibitor 99.95%
    9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis.
  • HY-171152A
    NSC 357754 dihydrochloride
    		Inhibitor 98.01%
    NSC 357754 dihydrochloride is an inhibitor of Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15.
  • HY-171152
    NSC 357754
    		Inhibitor
    NSC 357754 is an inhibitor of Claudin. NSC 357754 can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15.
  • HY-P991564
    Arcotatug
    		Inhibitor
    Arcotatug is a CLDN18.2 targeting humanized monoclonal antibody. Arcotatug can be used for synthesis of ADC.
  • HY-P991200
    OM-7D3-B3
    		Inhibitor
    OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (Kd = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection.
  • HY-P991163
    Tixentamig
    		Inhibitor
    Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers.