2. Signaling Pathways
  3. Cytoskeleton
  4. Cadherin
  5. Cadherin Agonist

Cadherin Agonist

Cadherin Agonists (3):

Cat. No. Product Name Effect Purity
  • HY-P11354
    THR-123
    		Agonist
    THR-123 is an orally active ALK3 peptide agonist. THR-123 has a relatively weak binding to ALK2, but does not bind to ALK6. THR-123 suppresses inflammation, apoptosis and the epithelial-to-mesenchymal transition program and reverses established fibrosis in five mouse models of acute and chronic renal injury. THR-123 can be used for the study of kidney fibrosis.
  • HY-175815
    Apoptosis inducer 44
    		Agonist
    Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer.
  • HY-P11346
    N-Cadherin mimic peptide
    		Agonist
    N-Cadherin mimic peptide is a N-cadherin agonist. N-Cadherin mimic peptide promotes N-cadherin homodimerization via enhancing β-catenin signaling, inducing early chondrogenesis and cartilage matrix production in mesenchymal stem cells (MSCs). N-Cadherin mimic peptide is promising for research of MSC-based cartilage regeneration.