2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. c-Fms

c-Fms

CSF-1 receptor; colony stimulating factor 1 receptor; CSF-1R; CSF1R

c-Fms

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c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. c-FMS is the cell surface receptor for IL-34 and CSF1. c-FMS has important roles in haematopoiesis, regulation of proliferation, cell survival and maturation of microglia and monocytes, as well as in controlling the overall immune response.

c-FMS is specifically expressed in osteoclasts and myelomonocytic-lineage cells, such as monocytes and macrophages, and the activation of c-FMS signaling promotes the proliferation or differentiation of these cells. It also promotes the production of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL6).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10917R
    GW2580 (Standard)
    		Inhibitor
    GW2580 (Standard) is the analytical standard of GW2580. This product is intended for research and analytical applications. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling.
    GW2580 (Standard)
  • HY-125377
    Leustroducsin C
    		Inducer
    Leustroducsin C is a colony-stimulating factor (CSF) inducer. Leustroducsin C induces production of CSF by bone marrowstromal cells.
    Leustroducsin C
  • HY-50751S
    Linifanib-d4
    		Inhibitor
    Linifanib-d4 (ABT-869-d4; AL-39324-d4) is deuterium-labeled Linifanib (HY-50751).
    Linifanib-d<sub>4</sub>
  • HY-159503A
    Segigratinib hydrochloride
    		Inhibitor
    Segigratinib hydrochloride (3D185) is a potent inhibitor of FGFR1/2/3 and CSF-1R; The IC50 values for FGFR1, FGFR2, FGFR3 and CSF-1R are 0.5, 1.3, 3.6 and 3.8 nM, respectively. Segigratinib hydrochloride has antitumor activity.
    Segigratinib hydrochloride
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity