2. Signaling Pathways
  3. GPCR/G Protein
  4. Arrestin
  5. Arrestin-2/β-Arrestin 1 Isoform
  6. Arrestin-2/β-Arrestin 1 Inhibitor

Arrestin-2/β-Arrestin 1 Inhibitor

Arrestin-2/β-Arrestin 1 Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-175197
    MP1202
    		Inhibitor
    MP1202 is a dual-functional agonist of MOR and KOR with EC50s of 0.32 and 0.13  μM for mMOR-1 and mKOR-1, respectively. MP1202 has functional selectivity with reduction of β-arrestin1/2 recruitment but significant activation of G-protein and Gα-subtype at hMOR and hKOR. MP1202 has potent antinociceptive effects without typical opioid side effects, but it shows conditioned place preference and aversion behaviors in subtype-selective opioid KO mice model, promising for analgesia research.