2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

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Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118220
    EP 171
    		Agonist
    EP 171 is a TP receptor agonist and human platelet activator. EP 171 can induce constriction of guinea pig trachea, and the constriction can be inhibited by the TP receptor antagonist EP 092. EP 171 binds to TP receptors on intact human platelets with an IC50 of 2.9 nM.
    EP 171
  • HY-114164F
    Canine Thrombin
    Canine Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.
    Canine Thrombin
  • HY-P4721
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM.
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
  • HY-P1493
    Fibrinopeptide B, human
    Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.
    Fibrinopeptide B, human
  • HY-N3097R
    Pellitorine (Standard)
    		Inhibitor
    Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.
    Pellitorine (Standard)
  • HY-123550
    Rosenonolactone
    		Inhibitor
    Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein.
    Rosenonolactone
  • HY-P5889
    Thrombin receptor peptide ligand
    		Antagonist
    Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent.
    Thrombin receptor peptide ligand
  • HY-114164E
    Rabbit Thrombin
    Rabbit Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.
    Rabbit Thrombin
  • HY-10270
    Flovagatran
    		Inhibitor
    Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
    Flovagatran
  • HY-P1636
    Hirudin (54-65)
    		Inhibitor
    Hirudin (54-65) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.
    Hirudin (54-65)
  • HY-P4259
    Hirullin P18
    		Inhibitor
    Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect.
    Hirullin P18
  • HY-10273
    Atecegatran metoxil
    		Inhibitor
    Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.
    Atecegatran metoxil
  • HY-11090A
    DPC423
    		Inhibitor
    DPC423 is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 has demonstrated antithrombotic effects in animal models, and when used in combination with Aspirin (HY-14654), it shows a strong synergistic effect. DPC423 can be used for the study of anticoagulation of arterial thrombosis.
    DPC423
  • HY-P1100
    PM102
    		Antagonist
    PM102 (HepArrest) is a heparin antagonist that can reverses the anticoagulant effect of heparin. PM102 potently binds heparin (Kd = 36 nM) in vitro.
    PM102
  • HY-14936
    Sofigatran
    		Inhibitor
    Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease.
    Sofigatran
  • HY-N10762
    15,16-Dihydrotanshindiol C
    		Inhibitor
    15,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor.
    15,16-Dihydrotanshindiol C
  • HY-177804
    Thrombin aptamer sodium
    		Inhibitor
    Thrombin aptamer is a 11mer-DNA aptamer that targets thrombin. Thrombin aptamer inhibites thrombin-catalysed fibrin-clot formation in vitro
    Thrombin aptamer sodium
  • HY-P4475
    Sar-Pro-Arg-pNA
    Sar-Pro-Arg-pNA is a chromogenic substrate of α-thrombin. Sar-Pro-Arg-pNA can be used to test α-thrombin activity.
    Sar-Pro-Arg-pNA
  • HY-105383
    L 373890
    		Inhibitor
    L 373890 is a selective pyridinone acetamide thrombin inhibitor with a Ki of 0.5 nM. L 373890 shows highly selectivity for thrombin over trypsin (Ki of 570 nM), serine proteases plasmin, tPA, activated protein C, plasma kallikrein and chymotrypsin. L 373890 can be used for thrombosis research.
    L 373890
  • HY-114603
    Efegatran
    		Inhibitor
    Efegatran (LY 294468) is an inhibitor for thrombin, which inhibits aggregation of platelets, and exhibits anticoagulant and antithrombotic activities.
    Efegatran
Cat. No. Product Name / Synonyms Application Reactivity