Syk

Spleen tyrosine kinase

Syk

Related Products

Syk (Spleen tyrosine kinase) is a cytosolic non-receptor protein tyrosine kinase (PTK) that is expressed at high levels, both in hematopoietic cells (such as mast cells, B lymphocytes, T lymphocytes, neutrophils, dendritic cells, and macrophages) and in non-hematopoietic cells.

Syk mediates key signal transduction pathways following the activation of immune cell receptors. Syk associates with different receptors on the surface of various cells such as B cells, mast cells, monocytes, macrophages, and neutrophils, and even osteoclasts and breast cancer cells. Following the engagement of these receptors with their ligands, SYK is activated and orchestrates diverse cellular responses, including cytokine production (in T cells and monocytes) and phagocytosis (in macrophages).

Syk Related Products (69):

By Effects:	Ligand (1) Inhibitors (66)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-160930

TOP1288	Inhibitor
TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC₅₀ of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts.

HY-174284

Syk-IN-13	Inhibitor
Syk-IN-13 is a Syk inhibitor, and can be used for research of rheumatoid arthritis and/or systemic lupus.

HY-13038BR

Fostamatinib disodium hexahydrate (Standard)	Inhibitor
Fostamatinib (disodium hexahydrate) (Standard) is the analytical standard of Fostamatinib (disodium hexahydrate). This product is intended for research and analytical applications. Fostamatinib (R788) disodium hexahydrate is the oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

HY-N7314

Asebogenin	Inhibitor
Asebogenin has antimalarial activity in vitro. Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps.

HY-13038R

Fostamatinib Disodium (Standard)	Inhibitor
Fostamatinib Disodium (Standard) is the analytical standard of Fostamatinib Disodium. This product is intended for research and analytical applications. Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

HY-13518R

Piceatannol (Standard)	Inhibitor
Piceatannol (Standard) is the analytical standard of Piceatannol. This product is intended for research and analytical applications. Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.

HY-123625

R-348 choline	Inhibitor
R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection.

HY-13038AR

Fostamatinib (Standard)	Inhibitor
Fostamatinib (Standard) is the analytical standard of Fostamatinib. This product is intended for research and analytical applications. Fostamatinib (R788) is the oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM. R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM).

HY-120533

Syk-IN-11	Inhibitor
Syk-IN-11 (BIIB-057) is a selective Syk inhibitor with an IC₅₀ Of 13 nM. Syk-IN-11 can be used in the study of arthritis and chronic lymphocytic leukemia.

Name
Email *

	Sorry, but the email address you supplied was invalid.