2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123033C
    Nicotinamide riboside malate
    		Activator
    Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside malate
  • HY-B0150S1
    Nicotinamide-15N,13C3
    		Inhibitor
    Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide-<sup>15</sup>N,<sup>13</sup>C<sub>3</sub>
  • HY-RS12944
    Sirt3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt3 Mouse Pre-designed siRNA Set A
    Sirt3 Mouse Pre-designed siRNA Set A
  • HY-163698
    SIRT-IN-4
    		Inhibitor
    SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC50=0.35 μM). SIRT-IN-4 is a potent Sirt2 deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study Sirt2 in cell cycle regulation, gene expression regulation, etc.
    SIRT-IN-4
  • HY-146386
    SIRT5 inhibitor 2
    		Inhibitor
    SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with an IC50 value of 2.3 μM. SIRT5 inhibitor 2 has inhibitory activity against the SIRT5-dependent desuccinylation. SIRT5 inhibitor 2 can be used for researching cancer and neurodegenerative diseases.
    SIRT5 inhibitor 2
  • HY-158162
    SIRT3 activator 1
    		Activator
    SIRT3 activator 1 (Compound 5v) is a SIRT3 activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases.
    SIRT3 activator 1
  • HY-148322
    Sirtuin modulator 5
    		Modulator
    Sirtuin modulator 5 is a sirtuin modulating agent. Sirtuin modulator 5 can activate SIRT1 with a DC50 value of <50 μM. Sirtuin modulator 5 can be used for increasing the lifespan of a cell and used for the research of variety of diseases including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity.
    Sirtuin modulator 5
  • HY-126904
    ZINC08792355
    		Inhibitor
    ZINC08792355 is a SIRT1 inhibitor and can be used for study of ageing, diabetes, and cancer..
    ZINC08792355
  • HY-N0341R
    Scopolin (Standard)
    		Activator
    Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades.
    Scopolin (Standard)
  • HY-155988
    Sirtuin modulator 6
    		Modulator
    Sirtuin modulator 6 (compound 262) increases the lifespan of a cell. Sirtuin modulator 6 can be used for study of diabetes, obesity, neurodegenerative diseases, cardiovascular disease, and so an extracted from patent WO2009064913A1.
    Sirtuin modulator 6
  • HY-168681
    Sirtuin-IN-2
    		Inhibitor
    Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, which is a key target for leukemia and breast cancer.
    Sirtuin-IN-2
  • HY-136094
    SRT3657
    		Activator
    SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
    SRT3657
  • HY-111317
    SIRT1 activator 3
    		Activator
    SIRT1 activator 3 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. SIRT1 activator 3 has the potential for anti-obesity or anti-diabetic researches.
    SIRT1 activator 3
  • HY-W841840
    SR94
    		Inhibitor
    SR94, a SR17 derivative, is a SIRT2 inhibitor that contains an arbitrary 6-member ring and different R2 groups. SR94 is promising for research of cancer, ischemia-reperfusion and neurodegenerative diseases.
    SR94
  • HY-RS12953
    SIRT7 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT7 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIRT7 Human Pre-designed siRNA Set A
    SIRT7 Human Pre-designed siRNA Set A
  • HY-16561G
    Resveratrol (GMP)
    		Activator
    Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol (GMP)
  • HY-149637
    HSP70/SIRT2-IN-1
    		Inhibitor
    HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity.
    HSP70/SIRT2-IN-1
  • HY-114981
    SRTCX1002
    		Activator
    SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively.
    SRTCX1002
  • HY-RS12951
    Sirt6 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt6 Mouse Pre-designed siRNA Set A
    Sirt6 Mouse Pre-designed siRNA Set A
  • HY-149426
    SIRT5 inhibitor 7
    		Inhibitor
    SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury.
    SIRT5 inhibitor 7
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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