2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-150727
    SIRT5 inhibitor 4
    		Inhibitor
    SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.
    SIRT5 inhibitor 4
  • HY-123033B
    Nicotinamide riboside tartrate
    		Activator
    Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside tartrate
  • HY-169159
    SIRT6 activator 2
    		Activator
    SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases.
    SIRT6 activator 2
  • HY-RS12955
    Sirt7 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sirt7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt7 Rat Pre-designed siRNA Set A
  • HY-155392
    Mz325
    		Inhibitor
    Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration.
    Mz325
  • HY-119857
    AGK7
    AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease.
    AGK7
  • HY-146013
    Sirt1/2-IN-1
    		Inhibitor
    Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.
    Sirt1/2-IN-1
  • HY-156023
    SIRT1 activator 2
    		Activator 99.28%
    SIRT1 activator 2 (compound 212) is a SIRT1 activator with an ED50 of < 5 μM. SIRT1 activator 2 can be used for increasing the lifespan of a cell.
    SIRT1 activator 2
  • HY-163676
    MI-217
    		Inhibitor
    MI-217 is a potent SIRT3 inhibitor. MI-217 induces MDA-MB-231 apoptosis. MI-217 can be used in the study of breast cancer.
    MI-217
  • HY-169051
    SIRT-IN-5
    		Inhibitor
    SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ.
    SIRT-IN-5
  • HY-148312
    Sirtuin modulator 4
    		Inhibitor
    Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC50 value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer.
    Sirtuin modulator 4
  • HY-149638
    HSP70/SIRT2-IN-2
    		Inhibitor
    HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity.
    HSP70/SIRT2-IN-2
  • HY-136204
    Resveratrol analog 2
    		Agonist
    Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
    Resveratrol analog 2
  • HY-169809
    SIRT1-IN-5
    		Inhibitor
    SIRT1-IN-5 (215) is a NAD-dependent protein deacetylase sirtuin-1 modulator.
    SIRT1-IN-5
  • HY-160617
    SIRT2-IN-14
    		Inhibitor
    SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC50 of 0.196 μM.
    SIRT2-IN-14
  • HY-155729
    Sirt1/2-IN-4
    		Inhibitor
    Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity.
    Sirt1/2-IN-4
  • HY-RS12949
    Sirt5 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sirt5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt5 Rat Pre-designed siRNA Set A
  • HY-B0150S1
    Nicotinamide-15N,13C3
    		Inhibitor
    Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide-<sup>15</sup>N,<sup>13</sup>C<sub>3</sub>
  • HY-163698
    SIRT-IN-4
    		Inhibitor
    SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC50=0.35 μM). SIRT-IN-4 is a potent Sirt2 deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study Sirt2 in cell cycle regulation, gene expression regulation, etc.
    SIRT-IN-4
  • HY-146386
    SIRT5 inhibitor 2
    		Inhibitor
    SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with an IC50 value of 2.3 μM. SIRT5 inhibitor 2 has inhibitory activity against the SIRT5-dependent desuccinylation. SIRT5 inhibitor 2 can be used for researching cancer and neurodegenerative diseases.
    SIRT5 inhibitor 2
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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