2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING

STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

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Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139586D
    Ulevostinag (isomer 4)
    		Agonist
    Ulevostinag isomer 4 (MK-1454 isomer 4) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
    Ulevostinag (isomer 4)
  • HY-N2616R
    Vomicine (Standard)
    		Inhibitor
    Vomicine (Standard) is the analytical standard of Vomicine. This product is intended for research and analytical applications. Vomicine modulates cGAS-STING-TBK1 signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds.
    Vomicine (Standard)
  • HY-W654000
    Cyclic GMP-13C,15N2
    		Activator
    Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators.
    Cyclic GMP-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-169483
    PDIC-NC
    		Agonist
    PDIC-NC is a STING agonist. PDIC-NC is cytotoxic to tumor cells and induces ROS explosion, apoptosis and autophagy. PDIC-NC has lung specific distribution and can be used in the study of lung cancer.
    PDIC-NC
Cat. No. Product Name / Synonyms Application Reactivity