2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Renin

Renin

Renin

Related Products

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Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (59):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1562
    Bopindolol
    		Inhibitor
    Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
    Bopindolol
  • HY-P2075
    EMD 55068
    		Antagonist
    EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate.
    EMD 55068
  • HY-50768
    VTP-27999
    		Inhibitor
    VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
    VTP-27999
  • HY-P2147
    CGP 29287
    		Inhibitor
    CGP 29287 is a specific renin inhibitor.
    CGP 29287
  • HY-P2024
    CP-85339
    		Inhibitor
    CP-85339 is a tetrapeptide renin inhibitor.
    CP-85339
  • HY-B1562B
    Bopindolol (malonate)
    		Inhibitor
    Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.
    Bopindolol (malonate)
  • HY-118033
    SQ 30774
    		Inhibitor
    SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo.
    SQ 30774
  • HY-105205
    Terlakiren
    		Inhibitor
    Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension.
    Terlakiren
  • HY-P2097
    L-363564
    		Inhibitor
    L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research.
    L-363564
  • HY-B0224A
    Chlorothiazide sodium
    		Inhibitor
    Chlorothiazide sodium is an orally active diuretic and anti-hypertensive agent.
    Chlorothiazide sodium
  • HY-P2060
    CGP 44099
    		Inhibitor
    CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts.
    CGP 44099
  • HY-12176AS
    Aliskiren-d6 hydrochloride
    		Inhibitor
    Aliskiren-d6 (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.
    Aliskiren-d<sub>6</sub> hydrochloride
  • HY-P2130
    SR 42128
    		Inhibitor
    SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited.
    SR 42128
  • HY-P5388
    Renin inhibitor peptide,rat
    		Inhibitor
    Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)
    Renin inhibitor peptide,rat
  • HY-106113
    Ditekiren
    		Inhibitor
    Ditekiren (U 71038) is a pseudohexapeptide renin inhibitor. Renin is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of renin, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction.
    Ditekiren
  • HY-123415
    PD 134922
    		Inhibitor
    PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease.
    PD 134922
  • HY-12172
    MK-8141
    		Inhibitor
    MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
    MK-8141
  • HY-12177S
    Aliskiren-d6 hemifumarate
    		Inhibitor
    Aliskiren-d6 (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM.
    Aliskiren-d<sub>6</sub> hemifumarate
  • HY-129695
    PD 132002
    		Inhibitor
    PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure.
    PD 132002
  • HY-B0224R
    Chlorothiazide (Standard)
    		Modulator
    Chlorothiazide (Standard) is the analytical standard of Chlorothiazide. This product is intended for research and analytical applications. Chlorothiazide is an orally active diuretic and anti-hypertensive agent.
    Chlorothiazide (Standard)