2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras

Ras

Ras

Related Products

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112666
    Farnesyl thiosalicylic acid amide
    		Inhibitor
    Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer.
    Farnesyl thiosalicylic acid amide
  • HY-115739
    RTIL 13
    		Inhibitor
    RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively.
    RTIL 13
  • HY-162971
    KRAS inhibitor-33
    		Inhibitor
    KRAS inhibitor-33 (compound 115a) is an inhibitor of pyridopyrimidine kras (IC50 ≤ 100nM).
    KRAS inhibitor-33
  • HY-124514
    UC-857993
    		Inhibitor
    UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs).
    UC-857993
  • HY-153555
    KRAS G12D modulator-1
    		Modulator
    KRAS G12D modulator-1 (compound 6) is a potent KRAS G12D modulator with IC50 values of 1-10 μM for NEA-G12D, PPI-G12D, and p ERK-AGS, respectively. KRAS G12D modulator-1 can be used in research of cancer.
    KRAS G12D modulator-1
  • HY-142945
    KRAS G12C inhibitor 43
    		Inhibitor
    KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively.
    KRAS G12C inhibitor 43
  • HY-170550
    KRAS G12C inhibitor 69
    		Inhibitor
    KRAS G12C inhibitor 69 (Compound K09) is the inhibitor for mutant RAS protein KRASG12C with an IC50 of 4.36 nM. KRAS G12C inhibitor 69 inhibits the ERK phosphorylation in NCI-H358 and MIA-PACA-2 with an IC50 of 12 nM and 7 nM. KRAS G12C inhibitor 69 inhibits the proliferation of cancer cell NCI-H358 and MIA-PACA-2 with IC50 of 3.15 nM and 2.33 nM.
    KRAS G12C inhibitor 69
  • HY-173329
    KRAS inhibitor-41
    		Inhibitor
    KRAS inhibitor-41 is an inhibitor of KRAS with IC50 values of <0.01 μM for KRAS G12D and KRAS G12V. KRAS inhibitor-41 inhibits RAS mutant cell lines, GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 can be used in cancer research.
    KRAS inhibitor-41
  • HY-202699
    SHOC2–RAS PPI-IN-1
    		Inhibitor
    SHOC2–RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor targeting the interaction between SHOC2 and RAS proteins. SHOC2–RAS PPI-IN-1 has an IC50 of 0.048 μM and a KD of 0.065 μM for NRASQ61R. SHOC2–RAS PPI-IN-1 can inhibit the activity of the SMP phosphatase complex, leading to increased CRAFS259 phosphorylation levels, thereby blocking the MAPK signaling pathway (such as reducing the levels of pMEK and pERK), inducing tumor cell cycle arrest and apoptosis. SHOC2–RAS PPI-IN-1 can be used for targeted research on malignant tumors such as melanoma and colorectal cancer with NRASQ61R mutations.
    SHOC2–RAS PPI-IN-1
  • HY-145047
    SOS1-IN-4
    		Inhibitor
    SOS1-IN-4 is a potent SOS1 inhibitor with an IC50 of 56 nM for KRAS-C12C/SOS1 interaction (WO2021228028 A1, example 65).
    SOS1-IN-4
  • HY-147631
    KRAS G12C inhibitor 50
    		Inhibitor
    KRAS G12C inhibitor 50 (Example 4) is a KRAS G12C inhibitor with an IC50 of 46.7 nM.
    KRAS G12C inhibitor 50
  • HY-162440
    pan-KRAS-IN-7
    		Inhibitor
    pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.35 and 0.51 nM, respectively.
    pan-KRAS-IN-7
  • HY-172626
    KRAS G12D inhibitor 28
    		Inhibitor
    KRAS G12D inhibitor 28 (Compound 1) is a KRAS G12D inhibitor. KRAS G12D inhibitor 28 (Compound 1) can be used in the cancer research.
    KRAS G12D inhibitor 28
  • HY-163720
    KRAS G12C inhibitor 63
    		Inhibitor
    KRAS G12C inhibitor 63 (K45) is a KRAS G12C inhibitor. KRAS G12C inhibitor 63 can induce Apoptosis. KRAS G12C inhibitor 63 has antitumor activity.
    KRAS G12C inhibitor 63
  • HY-147636
    KRAS G12C inhibitor 55
    		Inhibitor
    KRAS G12C inhibitor 55 (Compound 1) is a KRAS G12C inhibitor.
    KRAS G12C inhibitor 55
  • HY-147632
    KRAS G12C inhibitor 51
    		Inhibitor
    KRAS G12C inhibitor 51 (example 1) is a KRAS G12C inhibitor.
    KRAS G12C inhibitor 51
  • HY-148878
    Ras modulator-1
    		Modulator
    Ras modulator-1 is a modulator of Ras. Ras modulator-1 is an active compound extracted from patent US20120302581.
    Ras modulator-1
  • HY-161636
    PROTAC SOS1 degrader-9
    		Degrader
    PROTAC SOS1 degrader-9 (Compd 10) is a PROTAC-based SOS1 degrader (Red: SOS1 Ligand (HY-161635), Black: linker (HY-W056267), Blue: E3 ligase ligand (HY-161639)).
    PROTAC SOS1 degrader-9
  • HY-121532
    (-)-Rasfonin
    		Inhibitor
    (-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line).
    (-)-Rasfonin
  • HY-P1383A
    Rac1 Inhibitor F56, control peptide TFA
    		Inhibitor
    Rac1 Inhibitor F56, control peptide TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide TFA contains a Trp56 to Phe56 mutation. Rac1 Inhibitor F56, control peptide TFA has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs).
    Rac1 Inhibitor F56, control peptide TFA
Cat. No. Product Name / Synonyms Application Reactivity
Ras Isoform Comparison

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