Protease Activated Receptor (PAR)

Protease Activated Receptor (PAR) Related Products (34):

By Effects:	Inhibitors (4) Controls (3) Agonists (9) Antagonists (11) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-P4803

PAR-2 (1-6) (human)	Agonist	99.74%
PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist.

HY-14351

AC-264613	Agonist	98.3%
AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC₅₀ of 7.5.

HY-P2519A

Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA	Agonist	99.86%
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-P4987

TRAP-7	Activator	99.66%
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research.

HY-P5360

TFLLRN-NH2	Agonist	99.34%
TFLLRN-NH2 is a biological active peptide. (PAR-1 Agonist)

HY-114164C

Thrombin, Pig blood	Agonist
Rabbit Thrombin is a Na⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

HY-120544

BAY-386	Antagonist
BAY-386 is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC.

HY-169817

PAR-2-IN-2	Inhibitor
PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC₅₀ of 10.79 μM for SLIGKV and an IC₅₀ of greater than 200 μM for Trypsin.

HY-P5875A

P4pal10 TFA	Antagonist	98.25%
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models.

HY-P4004

PAR-4 (1-6) amide (human)		98.82%
PAR-4 (1-6) amide human is an N-terminal fragment of protease-activated receptor 4 (PAR4). PAR-4 (1-6) amide human induce platelet aggregation.

HY-124663

CBK289001	Inhibitor
CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5b^MV, TRAP 5b^OX and TRAP 5a^OX with IC₅₀s of 125 µM, 4.21 µM and 14.2 µM, respectively.

HY-P1312A

LRGILS-NH2 TFA	Control	98.90%
LRGILS-NH2 TFA is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide.

HY-P5358

YFLLRNP	Agonist	98.57%
YFLLRNP is a biological active peptide. (a partial agonist of PAR-1. YFLLRNP selectively active G12/13 signaling pathway without activating Gq or Gi pathways at low concentrations. YFLLRNP (60 μM))

HY-105999B

APC 366 TFA	Inhibitor	≥99.0%
APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases.

HY-W006069

H-Phe(3,5-DiF)-OH
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction.

HY-P1536

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

HY-10119S

Vorapaxar-d₅	Antagonist
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.

HY-P2519

Protease-Activated Receptor-3 (PAR-3) (1-6), human	Agonist
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-P1312

LRGILS-NH2	Control
LRGILS-NH2 is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide.

HY-P1311A

RLLFT-NH2 TFA	Control
RLLFT-NH2 TFA is a reversed amino acid sequence negative control peptide for TFLLR-NH2 (HY-P0226).

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