2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

Related Products

PDF 2.61 MB

Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5982
    PTPσ Inhibitor, ISP
    		Inhibitor
    PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS).
    PTPσ Inhibitor, ISP
  • HY-P0320B
    EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)
    		99.00%
    EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity.
    EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)
  • HY-149760
    PVD-06
    		Inhibitor
    PVD-06 is a selective PROTAC-class PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold) with anticancer activity. PVD-06 induces PTPN2 degradation via ubiquitination and proteasome-dependent pathways. PVD-06 can promote T cell activation and amplify IFN-γ-mediated cytotoxicity. PVD-06 consists of a target protein ligand (red part) PTPN2 ligand 1 (HY-168691), a PROTAC linker (black part) 6-Aminocaproic acid (HY-B0236), and an E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC-Me (HY-112078). E3 ubiquitin ligase+linker can form 6-Aminocaproic acid-(S,R,S)-AHPC-Me (HY-168690).
    PVD-06
  • HY-115671
    KLH45b
    		Inhibitor 99.99%
    KLH45b is an inhibitor of DDHD2 (DDHD domain containing 2).
    KLH45b
  • HY-15832A
    (R)-GSK 2830371
    		99.69%
    (R)-GSK 2830371 is the R-enantiomer of GSK 2830371 (HY-15832). GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.
    (R)-GSK 2830371
  • HY-103079
    PRL-3 Inhibitor 2
    		Inhibitor ≥98.0%
    PRL-3 Inhibitor 2 (compound 2) is a potent PRL-3 inhibitor with an IC50 value of 28.1 µM.
    PRL-3 Inhibitor 2
  • HY-142682
    SCP1-IN-1
    		Inhibitor 98.63%
    SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity.
    SCP1-IN-1
  • HY-163782
    SMIP-031
    		Inhibitor
    SMIP-031 is a potent and orally active PPM1A inhibitor with an IC50 value of 180 nM. SMIP-031 induces autophagy. SMIP-031 inhibits Mycobacterium tuberculosis infect in mice.
    SMIP-031
  • HY-W024644
    Hydroxyethylthio Vitamine K3
    Hydroxyethylthio Vitamin K3 is a Cdc25 phosphatase inhibitor, with IC50 values of 4.56 μM and 23.63 μM for Cdc25A and Cdc25B, respectively. Hydroxyethylthio Vitamin K3 can be used in tumor research.
    Hydroxyethylthio Vitamine K3
  • HY-118529
    JUN-1111
    		Inhibitor 98.57%
    JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1.
    JUN-1111
  • HY-121932
    Naphthol AS-BR
    		≥98.0%
    Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase.
    Naphthol AS-BR
  • HY-W040295
    Fast Red ITR
    		98.87%
    Fast Red ITR is a nonlinear optical material. Fast Red ITR can be used in alkaline phosphatase histochemistry.
    Fast Red ITR
  • HY-115605
    CN009543V
    		Inhibitor 99.37%
    CN009543V is an epidermal growth factor receptor (EGFR) agonist. CN009543V enhances tyrosine phosphorylation of EGFR at Tyr1068 and Tyr1173, thereby activating the MAPK/ERK cascade. CN009543V inhibits the activity of PTP-1B in MDA MB468 cells. CN009543V can be used in cancer research.
    CN009543V
  • HY-21196A
    Potassium perfluorohexanesulfonate
    		≥98.0%
    Potassium perfluorohexanesulfonate is an orally active surfactant found in sera of the general population. Potassium perfluorohexanesulfonate induces adaptive hepatocellular hypertrophy, decreases serum cholesterol and increases alkaline phosphatase in male mice.
    Potassium perfluorohexanesulfonate
  • HY-112929B
    (1S,2S,3R)-DT-061
    		99.77%
    (1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis.
    (1S,2S,3R)-DT-061
  • HY-N10378
    Rubrofusarin 6-O-β-D-glucopyranoside
    		Inhibitor 99.74%
    Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC50 of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression.
    Rubrofusarin 6-O-β-D-glucopyranoside
  • HY-W072940
    Anticancer agent 7
    		Activator 99.26%
    Anticancer agent 7 (Example 5) modulates PP2A, and induces FOXOl transcription factor translocation to the nucleus. Anticancer agent 7 inhibits the proliferation of H1650 lung cancer cell with an IC50 of 5 μM.
    Anticancer agent 7
  • HY-W002314
    2-Bromo-4'-hydroxyacetophenone
    		Inhibitor 98.59%
    2-Bromo-4'-hydroxyacetophenone a PTP1B inhibitor, with a Ki of 42 μM.
    2-Bromo-4'-hydroxyacetophenone
  • HY-N6785A
    Okadaic acid sodium
    		Inhibitor 99.90%
    Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation.
    Okadaic acid sodium
  • HY-12219
    MSI-1436
    		Inhibitor
    MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of appr 1 μM, 200-fold preference over TCPTP (IC50, 224 μM).
    MSI-1436
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity