2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2362
    DL-Alanine
    		≥98.0%
    DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver.
    DL-Alanine
  • HY-N3686
    D-Arabitol
    		98.0%
    D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.
    D-Arabitol
  • HY-Y1366
    Hydroxyacetone
    		≥98.0%
    Hydroxyacetone is a dehydration product of glycerol. Hydroxyacetone is a platform for the electrocatalytic synthesis of acetone, 1,2-propanediol and 2-propanol. Hydroxyacetone can also be used as a glycerol substitute for electrocatalytic hydrogenation and hydrodeoxygenation processes.
    Hydroxyacetone
  • HY-126833A
    Myristoyl coenzyme A lithium
    Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.
    Myristoyl coenzyme A lithium
  • HY-B0439
    Sulfadoxine
    		98.64%
    Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.
    Sulfadoxine
  • HY-W010448
    Imidazol-1-yl-acetic acid
    		99.91%
    Imidazol-1-yl-acetic acid is an endogenous metabolite.
    Imidazol-1-yl-acetic acid
  • HY-N8060A
    Orotidine 5′-monophosphate trisodium
    		99.86%
    Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT).
    Orotidine 5′-monophosphate trisodium
  • HY-N0390S5
    L-Glutamine-1-13C
    		98.0%
    L-Glutamine-1-13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine-1-<sup>13</sup>C
  • HY-113161
    L-Octanoylcarnitine
    		≥99.0%
    L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer.
    L-Octanoylcarnitine
  • HY-W010970
    5'-Guanylic acid disodium salt
    		99.53%
    5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations.
    5'-Guanylic acid disodium salt
  • HY-P2159
    Dynorphin A (1-8)
    		99.88%
    Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM).
    Dynorphin A (1-8)
  • HY-N0473S8
    L-Tyrosine-d2
    		99.81%
    L-Tyrosine-d2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d<sub>2</sub>
  • HY-W004206
    2-(4-Methoxyphenyl)acetic acid
    		99.95%
    2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.
    2-(4-Methoxyphenyl)acetic acid
  • HY-Y0191
    α-Pyridone
    		99.88%
    α-Pyridone (2-Pyridone) is an antibacterial agent. α-Pyridone can be synthesized via the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination. α-Pyridone can also be used to synthesize a wide range of heterocyclic compounds.
    α-Pyridone
  • HY-W015883S
    Fumaric acid-13C4
    		98.0%
    Fumaric acid-13C4 is the 13C-labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
    Fumaric acid-<sup>13</sup>C<sub>4</sub>
  • HY-W003445
    4-Bromo-3-hydroxybenzoic acid
    		99.25%
    4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes.
    4-Bromo-3-hydroxybenzoic acid
  • HY-N0379S22
    D-Mannose-13C6
    		98.0%
    D-Mannose-13C6 is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific proteins.
    D-Mannose-<sup>13</sup>C<sub>6</sub>
  • HY-145542
    Isovalerylcarnitine chloride
    		99.48%
    Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils.
    Isovalerylcarnitine chloride
  • HY-34439
    2,5-Dimethylpyrazine
    		99.81%
    2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite. 2,5-Dimethylpyrazine in produced in food systems of two whey protein hydrolysates, obtained using either trypsin or proteinase from Aspergillus melleus. 2,5-Dimethylpyrazine can be qualitatively monitored using a stable isotope dilution assay. 2,5-Dimethylpyrazine can also be generated via microbial mechanisms using Bacillus subtilis. 2,5-Dimethylpyrazine can be oxidized to form 5-methylpyrazine-2-carboxylic acid, which is the intermediate in the synthesis of antilipoltic agent. 2,5-Dimethylpyrazine is a volatile compound that can give a roasted peanut flavor.
    2,5-Dimethylpyrazine
  • HY-P2983
    Angiotensin-converting enzyme
    Angiotensin-converting enzyme (Kininase II) is a dicarboxypeptidase, it converts inactive Angiotensin I (Ang I) to active Ang II and degrades active bradykinin (BK). Angiotensin-converting enzyme is a potent vasoconstrictor, is often used in biochemical studies.
    Angiotensin-converting enzyme
Cat. No. Product Name / Synonyms Application Reactivity