2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1776S
    Spermidine-d6
    Spermidine-d6 is the deuterium labeled Spermidine. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents.
    Spermidine-d<sub>6</sub>
  • HY-Z0031
    (R)-(-)-1,2-Propanediol
    		99.93%
    (R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes.
    (R)-(-)-1,2-Propanediol
  • HY-W096638A
    Glycerophosphocholine
    		98.89%
    Glycerophosphocholine ((S)-Glycerolphosphocholine) is an intracellular metabolite during phosphatidylcholine metabolism and can be used to study the endogenous choline supply of cells. Glycerophosphocholine is used as a supplement in research into brain disorders.
    Glycerophosphocholine
  • HY-139101A
    Guanosine 5'-triphosphate-5'-adenosine triammonium
    		99.97%
    Guanosine 5'-triphosphate-5'-adenosine (GpppA) triammonium, a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine triammonium is a fluorescent substrate analog.
    Guanosine 5'-triphosphate-5'-adenosine triammonium
  • HY-16637R
    Folic acid (Standard)
    Folic acid (Standard) is the analytical standard of Folic acid. This product is intended for research and analytical applications. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
    Folic acid (Standard)
  • HY-104071
    Succinaldehydic acid
    Succinaldehydic acid is a catabolite of GABA.
    Succinaldehydic acid
  • HY-N0486R
    L-Leucine (Standard)
    L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine (Standard)
  • HY-30216A
    Leucic acid
    		99.16%
    Leucic acid is an amino acid metabolite.
    Leucic acid
  • HY-W587530
    6-Oxolithocholic acid
    		99.99%
    6-Oxolithocholic acid is a bile acid metabolite derived from Lithocholic acid (HY-B0172). 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis, especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bile acid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bile acids in health and disease, especially in the context of digestive and liver diseases.
    6-Oxolithocholic acid
  • HY-W004283S
    Pentadecanoic acid-d29
    		99.90%
    Pentadecanoic acid-d29 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
    Pentadecanoic acid-d<sub>29</sub>
  • HY-76082S
    L-Pyroglutamic acid-d5
    		98.6%
    L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid (HY-76082). L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
    L-Pyroglutamic acid-d<sub>5</sub>
  • HY-159648
    PF-07328948
    		99.88%
    PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats.
    PF-07328948
  • HY-115433
    α-Muricholic acid
    		99.0%
    α-Muricholic acid is the most abundant primary bile acid in rodents.
    α-Muricholic acid
  • HY-B0282S1
    Acetylcholine-d9 chloride
    		99.0%
    Acetylcholine-d9 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.
    Acetylcholine-d<sub>9</sub> chloride
  • HY-N0324S1
    Cholic acid-d5
    		98.0%
    Cholic acid-d5 is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
    Cholic acid-d<sub>5</sub>
  • HY-E70198
    Pepsin (MS Grade)
    Pepsin (MS Grade) is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin (MS Grade) contributes to proteolysis of food proteins in the vertebrate stomach.
    Pepsin (MS Grade)
  • HY-N1461
    Dihydrodaidzein
    		99.85%
    Dihydrodaidzein is one of the most prominent dietary phytoestrogens.
    Dihydrodaidzein
  • HY-W004661
    1,4-Dioxane-2,5-diol
    		98.0%
    1,4-Dioxane-2,5-diol is an endogenous metabolite.
    1,4-Dioxane-2,5-diol
  • HY-137499
    NT1-O12B
    		Chemical
    NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.
    NT1-O12B
  • HY-W016887
    Glycyl-L-proline
    		99.88%
    Glycyl-L-proline (H-Gly-Pro-OH) is an end product of collagen metabolism that is further cleaved by prolidase.
    Glycyl-L-proline
Cat. No. Product Name / Synonyms Application Reactivity