2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2963
    Nuclease P1
    Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries. Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc.
    Nuclease P1
  • HY-W012814
    4-Methylcatechol
    		99.52%
    4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation.
    4-Methylcatechol
  • HY-113529
    Stachyose tetrahydrate
    		98.10%
    Stachyose tetrahydrate, a functional oligosaccharide, acts as a prebiotic. Stachyose tetrahydrate can prevent indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine.
    Stachyose tetrahydrate
  • HY-Y0504
    Trimethylammonium chloride
    		≥98.0%
    Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase.
    Trimethylammonium chloride
  • HY-W041019
    5-Hydroxytryptophol
    		98.31%
    5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse.
    5-Hydroxytryptophol
  • HY-W013636R
    2-Ketoglutaric acid (Standard)
    2-Ketoglutaric acid (Standard) (Alpha-Ketoglutaric acid (Standard)) is the analytical standard of 2-Ketoglutaric acid (HY-W013636). This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid (Standard)
  • HY-21088
    3-Amino-2-piperidinone
    		99.93%
    3-amino-2-piperidinone is a cyclic ornithine analogue. 3-amino-2-piperidinone can be used to synthesize N-(2-oxopiperidin-3-yl)dodecanamide. N-(2-oxopiperidin-3-yl)dodecanamide inhibits Fas-induced Apoptosis.
    3-Amino-2-piperidinone
  • HY-W032013
    1-Octanol
    		99.63%
    1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.
    1-Octanol
  • HY-W011819
    Tetradecanedioic acid
    		≥98.0%
    Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs).
    Tetradecanedioic acid
  • HY-125773
    β-cyano-L-Alanine
    		99.0%
    β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates. β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury.
    β-cyano-L-Alanine
  • HY-A0181S1
    Adenosine monophosphate-15N5 dilithium
    		99.50%
    Adenosine monophosphate-15N5 dilithium is the 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-<sup>15</sup>N<sub>5</sub> dilithium
  • HY-W011256
    Adenosine 2',3'-cyclic phosphate sodium
    		99.10%
    Adenosine 2',3'-cyclic phosphate sodium is a 2',3'-cyclic purine nucleotide. Adenosine 2',3'-cyclic phosphate sodium is deaminated by the adenosine deaminase. Adenosine 2',3'-cyclic phosphate sodium can be degrade to 2'-AMP and 3'-AMP.
    Adenosine 2',3'-cyclic phosphate sodium
  • HY-76801
    24, 25-Dihydroxy VD2
    		99.58%
    24,25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a hydroxylated metabolite and derivative of Vitamin D2 HY-76542 (HY-76542).
    24, 25-Dihydroxy VD2
  • HY-113256
    Linoleyl carnitine
    		99.8%
    Linoleyl carnitine is an acylcarnitine used to study long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders in fibroblasts.
    Linoleyl carnitine
  • HY-128736C
    L-2-Phosphoglyceric acid sodium hydrate
    L-2-Phosphoglyceric acid sodium hydrate is an endogenous metabolite.
    L-2-Phosphoglyceric acid sodium hydrate
  • HY-B0228R
    Adenosine (Standard)
    Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine (Standard)
  • HY-113325A
    NADP sodium hydrate
    		99.03%
    NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
    NADP sodium hydrate
  • HY-P2657
    Verucopeptin
    Verucopeptin is a potent HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR) cancers and can be used for cancer research.
    Verucopeptin
  • HY-100805
    D-Glutamic acid
    		≥99.0%
    D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
    D-Glutamic acid
  • HY-B0442A
    Vardenafil hydrochloride
    		99.79%
    Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
    Vardenafil hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity