2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0384S
    Homovanillic acid-d3
    Homovanillic acid-d3 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid-d<sub>3</sub>
  • HY-B0539S1
    Desloratadine-d9
    Desloratadine-d9 is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities.
    Desloratadine-d<sub>9</sub>
  • HY-16637S1
    Folic acid-d4
    Folic acid-d4 is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
    Folic acid-d<sub>4</sub>
  • HY-W015591S
    Mandelic acid-2,3,4,5,6-d5
    Mandelic acid-2,3,4,5,6-d5 is the deuterium labeled Mandelic acid. Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation.
    Mandelic acid-2,3,4,5,6-d<sub>5</sub>
  • HY-17367S3
    Atazanavir-d5
    Atazanavir-d5 is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM.
    Atazanavir-d<sub>5</sub>
  • HY-136436S
    Ternidazole-d6 hydrochloride
    Ternidazole-d6 (hydrochloride) is the deuterium labeled Ternidazole hydrochloride. Ternidazole hydrochloride is a hydroxymetabolite of nitroimidazole, has antiprotozoic properties.
    Ternidazole-d<sub>6</sub> hydrochloride
  • HY-113279S
    7-Dehydrocholesterol-d7
    7-Dehydrocholesterol-d7 is the deuterium labeled 7-Dehydrocholesterol. 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.
    7-Dehydrocholesterol-d<sub>7</sub>
  • HY-17367S2
    Atazanavir-d9
    Atazanavir-d9 is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM.
    Atazanavir-d<sub>9</sub>
  • HY-19696S
    Tauroursodeoxycholate-d5
    Tauroursodeoxycholate-d5 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
    Tauroursodeoxycholate-d<sub>5</sub>
  • HY-13677S
    6-Mercaptopurine-d2
    6-Mercaptopurine-d2 is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
    6-Mercaptopurine-d<sub>2</sub>
  • HY-15762S
    Valdecoxib-d3
    Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.
    Valdecoxib-d<sub>3</sub>
  • HY-128733S
    Phenyl acetate-d5
    Phenyl acetate-d5 is the deuterium labeled Phenyl acetate. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression.
    Phenyl acetate-d<sub>5</sub>
  • HY-117275S
    Meclofenamic acid-d4
    Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
    Meclofenamic acid-d<sub>4</sub>
  • HY-126061S
    1,7-Dimethyluric acid-d3
    1,7-Dimethyluric acid-d3 is the deuterium labeled 1,7-Dimethyluric acid. 1,7-Dimethyluric acid is the metabolite of caffeine.
    1,7-Dimethyluric acid-d<sub>3</sub>
  • HY-B1941S
    4-tert-Octylphenol-3,5-d2
    4-tert-Octylphenol-3,5-d2 is the deuterium labeled 4-tert-Octylphenol-3,5.
    4-tert-Octylphenol-3,5-d<sub>2</sub>
  • HY-B0132S1
    Norfloxacin-d8
    Norfloxacin-d8 is the deuterium labeled Norfloxacin. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.
    Norfloxacin-d<sub>8</sub>
  • HY-W012722BS
    4-Methyl-2-oxopentanoic acid-d7 sodium
    4-Methyl-2-oxopentanoic acid-d7 (α-Ketoisocaproic acid-d7) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways.
    4-Methyl-2-oxopentanoic acid-d<sub>7</sub> sodium
  • HY-B0661CS
    (Rac)-Tamsulosin-d3 hydrochloride
    (Rac)-Tamsulosin-d3 (hydrochloride) is the deuterium labeled (Rac)-Tamsulosin hydrochloride.
    (Rac)-Tamsulosin-d<sub>3</sub> hydrochloride
  • HY-135212S
    Hydroxy ipronidazole-d3
    Hydroxy ipronidazole-d3 is the deuterium labeled Hydroxy ipronidazole. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound.
    Hydroxy ipronidazole-d<sub>3</sub>
  • HY-N0391S2
    L-Citrulline-d6
    L-Citrulline-d6 is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
    L-Citrulline-d<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity