2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121385
    Hydroxy bosentan
    		≥98.0%
    Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.
    Hydroxy bosentan
  • HY-N12706
    Heilaohuguosu G
    		≥98.0%
    Heilaohuguosu G (compound 7) is a cyclolignan with hepatoprotective activity. Heilaohuguosu G against APAP toxicity with cell survival rates at 10 μM of 45.7% in HepG-2 cells.
    Heilaohuguosu G
  • HY-N8063
    γ-Glutamylornithine
    		≥98.0%
    γ-Glutamylornithine is the urine excreta of patients with HHH syndrome (hyperuricemia, hyperaminemia, and hypercitrullinuria) and rotary atrophy associated with hyperuricemia. Increased levels of endogenous ornithine increase levels of γ-Glutamylornithine in the urine.
    γ-Glutamylornithine
  • HY-W010476
    2,3,5-Trimethylpyrazine
    		99.92%
    2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine
  • HY-113227R
    Oxoadipic acid (Standard)
    Oxoadipic acid (Standard) is the analytical standard of Oxoadipic acid. This product is intended for research and analytical applications. Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
    Oxoadipic acid (Standard)
  • HY-W012814R
    4-Methylcatechol (Standard)
    4-Methylcatechol (Standard) is the analytical standard of 4-Methylcatechol. This product is intended for research and analytical applications. 4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation[1][2][3][4][5][6].
    4-Methylcatechol (Standard)
  • HY-160850
    C18 Ceramide-1-phosphate (d18:1/18:0) ammonium salt
    		99.0%
    C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) is a specific type of long-chain molecule found in murine skin. C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt) promotes migration of both mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells at concentrations between 0.5-5 µM. C18 Ceramide-1-phosphate (d18:1/18:0) (ammonium salt)’s levels are higher in CFPAC-1 pancreatic ductal adenocarcinoma cells than in pancreatic cancer stem cells.
    C18 Ceramide-1-phosphate (d18:1/18:0) ammonium salt
  • HY-127009
    Levoleucovorin
    		98.53%
    Levoleucovorin (Levofolinic acid) is the pharmacologically active levoisomer of racemic leucovorin. Levoleucovorin can be used as a rescue agent after high-dose Methotrexate (HY-14519) therapy, and in combination with fluorouracil for the research of advanced metastatic colorectal cancer.
    Levoleucovorin
  • HY-116953
    Lipoxin B4
    		99.20%
    Lipoxin B4 (LXB4) is a structurally distinct product of arachidonic acid metabolism. Lipoxin B4 reduces leukocyte infiltration and mucus secretion in the nasal mucosa and decreases mast cell and eosinophil degranulation in the upper airway. Lipoxin B4 decreases airway inflammation, mucus metaplasia and hyper- responsiveness in the lower airway. Lipoxin B4 shows mucosal protective actions and has the potential for the research of allergic inflammation in the upper and lower airways.
    Lipoxin B4
  • HY-W002110
    Isohomovanillic acid
    		99.12%
    Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is extracted from urine at pH 2 by ethyl acetate. Isohomovanillic acid is not found in appreciable values in many normal human urines.
    Isohomovanillic acid
  • HY-113308S1
    Taurolithocholic acid-d4
    		98.36%
    Taurolithocholic acid-d4 is deuterium labeled Taurolithocholic acid.
    Taurolithocholic acid-d<sub>4</sub>
  • HY-134313A
    8-NH2-ATP tetrasodium
    		≥98.0%
    8-NH2-ATP tetrasodium, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado tetrasodium induces apoptosis-related cleavage of poly (ADP-ribose) polymerase.
    8-NH2-ATP tetrasodium
  • HY-P3219
    N-Acetyloxytocin
    N-Acetyloxytocin is isolated and characterized in the neurointermediate lobe of the rat pituitary (NIL) and their presence in several brain areas of the rat.
    N-Acetyloxytocin
  • HY-50723S
    3-Methylxanthine-13C4,15N3
    3-Methylxanthine-13C4,15N3 is the 13C-labeled and 15N-labeled 3-Methylxanthine. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
    3-Methylxanthine-<sup>13</sup>C<sub>4</sub>,<sup>15</sup>N<sub>3</sub>
  • HY-172548
    Docosahexaenoyl-L-carnitine chloride
    Docosahexaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Docosahexaenoic acid (HY-B2167) and L-carnitine (HY-B0399). Docosahexaenoyl-L-carnitine chloride is transported into mitochondria for β -oxidation and decomposition under the action of carnitine palmitoyltransferase I (CPT I) and others. Docosahexaenoyl-L-carnitine chloride is promising for research of diseases related to fatty acid metabolism.
    Docosahexaenoyl-L-carnitine chloride
  • HY-Y0248AR
    Farnesol (Standard)
    Farnesol (Standard) is the analytical standard of Farnesol. This product is intended for research and analytical applications. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
    Farnesol (Standard)
  • HY-B1971R
    Deltamethrin (Standard)
    Deltamethrin (Standard) is the analytical standard of Deltamethrin. This product is intended for research and analytical applications. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.
    Deltamethrin (Standard)
  • HY-111815
    N4-Acetylcytidine triphosphate
    N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates.
    N4-Acetylcytidine triphosphate
  • HY-P1179
    Guanylin(human)
    Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.
    Guanylin(human)
  • HY-116663
    (±)20-HDHA
    (±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate.
    (±)20-HDHA
Cat. No. Product Name / Synonyms Application Reactivity