2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135627
    JBP485
    JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases.
    JBP485
  • HY-101988S
    Prostaglandin D2-d4
    		98.8%
    Prostaglandin D2-d4 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation.
    Prostaglandin D2-d<sub>4</sub>
  • HY-P0070
    Thymus peptide C
    Thymus peptide C is a hormonal agent derived from the thymus glands of young calves, which works as a substitute for the physiological functions of the thymus.
    Thymus peptide C
  • HY-125516
    MCTR3
    		98.40%
    MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis.
    MCTR3
  • HY-113066S2
    Guanosine 5'-diphosphate-d13 dilithium
    Guanosine 5'-diphosphate-d13 (GDP-d13) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
    Guanosine 5'-diphosphate-d<sup>13</sup> dilithium
  • HY-N0771S7
    L-Isoleucine-15N,d10
    		≥98.0%
    L-Isoleucine-15N,d10 is the deuterium and 15N-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.
    L-Isoleucine-<sup>15</sup>N,d<sub>10</sub>
  • HY-114293A
    Acetyl coenzyme A trilithium
    Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis.
    Acetyl coenzyme A trilithium
  • HY-N0384S3
    Homovanillic acid-13C6,18O
    		99.2%
    Homovanillic acid-13C6,18O is the 13C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid-<sup>13</sup>C<sub>6</sub>,<sup>18</sup>O
  • HY-110296
    EC19
    EC19 is an analogue of 13-cis retinoic acid (HY-15127). EC19 shows embryo toxicity. EC19 causes mild effects on upper beak outgrowth.
    EC19
  • HY-113089A
    Epsilon-(gamma-glutamyl)-lysine TFA
    		98.55%
    Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration.
    Epsilon-(gamma-glutamyl)-lysine TFA
  • HY-158584
    13-OAHSA
    		99.00%
    13-OAHSA is one of fatty acid esters of hydroxy fatty acids (FAHFAs). 13-OAHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration.
    13-OAHSA
  • HY-115762
    4-Hydroxytryptamine creatinine sulfate
    		Agonist
    4-Hydroxytryptamine creatinine sulfate, a tryptamine derivative, is a neurotransmitter agonist.
    4-Hydroxytryptamine creatinine sulfate
  • HY-Y0069S1
    N-Acetylglycine-d2
    N-Acetylglycine-d2 (Aceturic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods. N-Acetylglycine is a flavor enhancer which elicits Monosodium glutamate (MSG)-like sensory experiencesN-Acetylglycine.
    N-Acetylglycine-d<sub>2</sub>
  • HY-N0304S1
    L-DOPA-13C6
    		≥98.0%
    L-DOPA-13C6 is the 13C-labled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
    L-DOPA-<sup>13</sup>C<sub>6</sub>
  • HY-128853S
    Taurodeoxycholate-d6 sodium salt
    		99.4%
    Taurodeoxycholate-d6 sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate-d6 sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate-d6 sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d6 (TDCA) exhibits anti-inflammatory and neuroprotective effects.
    Taurodeoxycholate-d<sub>6</sub> sodium salt
  • HY-W015618
    2',4'-Dimethylacetophenone
    		≥98.0%
    2',4'-Dimethylacetophenone is an endogenous metabolite.
    2',4'-Dimethylacetophenone
  • HY-100582R
    Ribitol (Standard)
    Ribitol (Standard) is the analytical standard of Ribitol. This product is intended for research and analytical applications. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol.
    Ribitol (Standard)
  • HY-W080443
    O-allylvanillin
    		98.41%
    O-allylvanillin is O-allylchalcone derivative with anti-cancer effects. O-allylvanillin inhibits THP-1, HL60, Hep-G2, MCF-7 cells growth with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively.
    O-allylvanillin
  • HY-W653842
    Taurocholic acid-d8 sodium
    		98.83%
    Taurocholic acid-d8 (sodium) is deuterium labeled Taurocholic acid (sodium). Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect.
    Taurocholic acid-d<sub>8</sub> sodium
  • HY-E70283
    Recombinant endoglycoceramidase II assisted by activator II
    Recombinant endoglycoceramidase II assisted by activator II is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
    Recombinant endoglycoceramidase II assisted by activator II
Cat. No. Product Name / Synonyms Application Reactivity