2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. JBP485

JBP485  (Synonyms: cyclo(L-Hyp-L-Ser))

Cat. No.: HY-135627 Purity: ≥95.0%
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JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases.

For research use only. We do not sell to patients.

JBP485 Chemical Structure

JBP485 Chemical Structure

CAS No. : 211868-63-2

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

JBP485 Related Antibodies

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Description

JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases[1].

In Vitro

JBP485 (1-100 μM, 24-96 h) accelerates proliferation of cultivated corneal epithelial cells (CECs) dose- and time-dependently[1].
JBP485 (1-100 μM, 15 h) accelerates migration of CECs dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JBP485 Related Antibodies
In Vivo

JBP485 (100 μM, topical application, 4 times per day) accelerates the corneal epithelial wound healing on rabbits (4 days for healing completely, compared with 5 days for control group)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

200.19

Formula

C8H12N2O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N[C@H]1CO)[C@@](C[C@@H](O)C2)([H])N2C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.5 mg/mL (37.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9953 mL 24.9763 mL 49.9525 mL
5 mM 0.9991 mL 4.9953 mL 9.9905 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9953 mL 24.9763 mL 49.9525 mL 124.8814 mL
5 mM 0.9991 mL 4.9953 mL 9.9905 mL 24.9763 mL
10 mM 0.4995 mL 2.4976 mL 4.9953 mL 12.4881 mL
15 mM 0.3330 mL 1.6651 mL 3.3302 mL 8.3254 mL
20 mM 0.2498 mL 1.2488 mL 2.4976 mL 6.2441 mL
25 mM 0.1998 mL 0.9991 mL 1.9981 mL 4.9953 mL
30 mM 0.1665 mL 0.8325 mL 1.6651 mL 4.1627 mL
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JBP485 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBP485211868-63-2cyclo(L-Hyp-L-Ser)JBP 485JBP-485Endogenous Metabolitedipeptideanti-hepatotoxicwound healingcorneal epithelialInhibitorinhibitorinhibit

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