2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112942
    CMP-Sialic acid
    CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.
    CMP-Sialic acid
  • HY-W015883S1
    Fumaric acid-13C2
    		99.9%
    Fumaric acid-13C2 is the 13C-labeled Fumaric acid (HY-W015883). Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension.
    Fumaric acid-<sup>13</sup>C<sub>2</sub>
  • HY-B1465S2
    1-Hexadecanol-d5
    		99.20%
    1-Hexadecanol-d5 is the deuterium labeled 1-Hexadecanol. 1-Hexadecanol is a fatty alcohol, a lipophilic substrate.
    1-Hexadecanol-d<sub>5</sub>
  • HY-B1449S11
    Uridine-13C9
    		99.00%
    Uridine-13C9 (β-Uridine-13C9) is a 13C9-labeled form of Uridine (HY-B1449). Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
    Uridine-<sup>13</sup>C<sub>9</sub>
  • HY-124258
    Valilactone
    		≥99.0%
    Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes.
    Valilactone
  • HY-113070
    Dihomo-γ-Linolenoyl Ethanolamide
    		≥99.0%
    Dihomo-γ-Linolenoyl Ethanolamide, an endocannabinoid, is a cannabinoid (CB) receptor agonist with Kis of 857 nM and 598 nM for human recombinant CB1 and CB2 receptors, respectively.
    Dihomo-γ-Linolenoyl Ethanolamide
  • HY-W015883S2
    Fumaric acid-13C2,d2
    		98.00%
    Fumaric acid-13C2,d2 is the deuterium and 13C labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
    Fumaric acid-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-158843
    15(S)-Hete-biotin
    15(S)-Hete-biotin (15(S)-Hydroxyeicosatetraenoic acid-biotin) can be used to detect 15(S)-HETE binding proteins and/or receptors. 15(S)-HETE is an arachidonic acid metabolite produced by the 15-lipoxygenase pathway.
    15(S)-Hete-biotin
  • HY-W012657
    4-Ethylbenzaldehyde
    		99.06%
    4-Ethylbenzaldehyde is an endogenous metabolite.
    4-Ethylbenzaldehyde
  • HY-101399A
    γ-Glu-Phe TFA
    		99.50%
    γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth.
    γ-Glu-Phe TFA
  • HY-P2976
    Lipoxygenase, general
    Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid.
    Lipoxygenase, general
  • HY-125538
    Deoxybrevianamide E
    		99.2%
    Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp..
    Deoxybrevianamide E
  • HY-N0729R
    Linoleic acid (Standard)
    Linoleic acid (Standard) is the analytical standard of Linoleic acid (HY-N0729). This product is intended for research and analytical applications. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
    Linoleic acid (Standard)
  • HY-N7103R
    Ethyl oleate (Standard)
    Ethyl oleate (Standard) is the analytical standard of Ethyl oleate. This product is intended for research and analytical applications. Ethyl oleate is an orally active fatty acid ester formed from the condensation of oleic acid and ethanol. Ethyl oleate is the main fatty acid ethyl ester in the blood after alcohol ingestion. Ethyl oleate has no obvious toxicity to rats and its absorption, distribution and excretionare similar to triacylglycerol. Ethyl oleate can accelerate the drying process of certain foods and can also be used as a liquid lipid component in nanostructured lipid carriers.
    Ethyl oleate (Standard)
  • HY-118824
    Moschamine
    		98.14%
    Moschamine acts as an inhibitor of excessive superoxide production in mitochondria.
    Moschamine
  • HY-W012382S
    N-Acetyl-L-tyrosine-d3
    		98.43%
    N-Acetyl-L-tyrosine-d3 is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer.
    N-Acetyl-L-tyrosine-d<sub>3</sub>
  • HY-126356
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is an endogenous metabolite.
    1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
  • HY-136234
    9-cis-β-Carotene
    9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus.
    9-cis-β-Carotene
  • HY-137129
    10-Formyl-7,8-dihydrofolic acid
    10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate.
    10-Formyl-7,8-dihydrofolic acid
  • HY-W010277
    (S)-2-(2-Aminopropanamido)acetic acid
    		≥98.0%
    (S)-2-(2-Aminopropanamido)acetic acid is a Glycine (HY-Y0966) derivative.
    (S)-2-(2-Aminopropanamido)acetic acid
Cat. No. Product Name / Synonyms Application Reactivity