2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10585S
    Valproic acid-d4
    		≥98.0%
    Valproic acid-d4 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
    Valproic acid-d<sub>4</sub>
  • HY-N0570S
    Hydroxytyrosol-d4
    Hydroxytyrosol-d4 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects.
    Hydroxytyrosol-d<sub>4</sub>
  • HY-W011848S
    Monobenzyl phthalate-d4
    		99.35%
    Monobenzyl phthalate-d4 is the deuterium labeled Monobenzyl phthalate. Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP).
    Monobenzyl phthalate-d<sub>4</sub>
  • HY-W017442
    DL-Asparagine
    		≥98.0%
    DL-Asparagine is a racemic melange of the Aparagine L and D-enantiomers. DL-Asparagine has been used in growth-media for bacteria-growth.
    DL-Asparagine
  • HY-N0111S2
    Coenzyme Q10-d9
    		98.23%
    Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10-d<sub>9</sub>
  • HY-W010708S
    Cholesteryl palmitate-d9
    		99.0%
    Cholesteryl palmitate-d9 is the deuterium labeled Cholesteryl palmitate. Cholesteryl palmitate is a useful prognostic biomarker for chronic interstitial pneumonia (CIP).
    Cholesteryl palmitate-d<sub>9</sub>
  • HY-131934
    9-OAHSA
    		≥99.0%
    9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-OAHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression. 9-OAHSA is also a protective molecule to prevent colon carcinoma cells from apoptotic cell death.
    9-OAHSA
  • HY-16637A
    Folic acid sodium
    Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
    Folic acid sodium
  • HY-B0710R
    Betaine (Standard)
    Betaine (Standard) is the analytical standard of Betaine. This product is intended for research and analytical applications. Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns[1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity.
    Betaine (Standard)
  • HY-W011819S
    Tetradecanedioic acid-d24
    		98.80%
    Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions.
    Tetradecanedioic acid-d<sub>24</sub>
  • HY-113143
    Galactose 1-phosphate
    Galactose 1-phosphate is an intermediate in the galactose metabolism and nucleotide sugars.
    Galactose 1-phosphate
  • HY-133588
    4-Formylaminoantipyrine
    		99.97%
    4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo.
    4-Formylaminoantipyrine
  • HY-W041171S
    3-Chloro-L-tyrosine-13C6
    3-Chloro-L-tyrosine-13C6 is the 13C labeled 3-Chloro-L-tyrosine. 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
    3-Chloro-L-tyrosine-<sup>13</sup>C<sub>6</sub>
  • HY-W002820
    2-Amino-5-phenylpyridine
    		99.91%
    2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic.
    2-Amino-5-phenylpyridine
  • HY-W014606
    L-Lysine acetate
    		≥98.0%
    L-Lysine acetate is an essential amino acid. L-Lysine acetate can be research for vascular calcification (VC) and Acute pancreatitis.
    L-Lysine acetate
  • HY-113167
    2-Phosphoglyceric acid
    2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolysis substrate. It is catalyzed by enolase into phosphoenolpyruvate (PEP).
    2-Phosphoglyceric acid
  • HY-111664A
    (S)​-​(-​)​-​Citronellal
    		99.66%
    (S)-(-)-Citronellal is a monoterpenoid compound derived from a biosynthetic pathway with mevalonic acid serving as the only carbon source. (S)-(-)-Citronellal can be found in Corymbia citriodora and Cymbopogon nardus essential oils. (S)-(-)-Citronellal can act as a starting material of cyclization process.
    (S)​-​(-​)​-​Citronellal
  • HY-113801
    N-(3-Oxooctanoyl)-DL-homoserine lactone
    		99.69%
    N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .
    N-(3-Oxooctanoyl)-DL-homoserine lactone
  • HY-128720
    Diethyl oxalpropionate
    Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release.
    Diethyl oxalpropionate
  • HY-130207
    Oncrasin-72
    Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma.
    Oncrasin-72
Cat. No. Product Name / Synonyms Application Reactivity