2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113246
    15-keto-Prostaglandin F2a
    		99.2%
    15-keto-Prostaglandin F2α (15-keto-PGF2α) is a metabolite of Prostaglandin F2α. Prostaglandin F2α. Prostaglandin F2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour.
    15-keto-Prostaglandin F2a
  • HY-118899
    XR5944
    XR5944 is an anti-tumor compound with DNA-targeting activity. As a topoisomerase inhibitor, XR5944 can effectively inhibit the activities of topoisomerase I and II. XR5944 shows excellent anti-tumor activity against human and mouse tumor cells in vitro and in vivo. XR5944 exhibits significant potency in multiple cell lines, with IC50 values of 0.04-0.4 nM. XR5944 is not affected by atypical drug resistance in cells and remains significantly active even in cells overexpressing P-glycoprotein or multidrug resistance-related proteins. XR5944 showed anti-tumor efficacy in human tumor models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in most animals in the HT29 model. XR5944 can be used to study biological processes related to colon and lung cancer.
    XR5944
  • HY-137878
    2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid
    2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) acts as a sialyl donor in the process of enzyme-catalyzed trans-sialylation.
    2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid
  • HY-B2227C
    Lactic acid potassium
    Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative.
    Lactic acid potassium
  • HY-136438
    Toltrazuril sulfoxide
    		99.55%
    Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
    Toltrazuril sulfoxide
  • HY-W015424
    N-Methyl-DL-glutamic acid
    		98.0%
    N-Methyl-DL-glutamic acid is a L-Glutamic acid (HY-14608) analog with cytotoxic effects.
    N-Methyl-DL-glutamic acid
  • HY-W008807S
    Phosphoenolpyruvic acid potassium-13C2
    Phosphoenolpyruvic acid (potassium)-13C2 is the 13C labeled Phosphoenolpyruvic acid potassium (HY-W008807). Phosphoenolpyruvic acid (Phosphoenolpyruvate) potassium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid potassium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid potassium also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid potassium-<sup>13</sup>C<sub>2</sub>
  • HY-N0583S3
    Hydrocortisone-d3
    		98.02%
    Hydrocortisone-d3 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone-d<sub>3</sub>
  • HY-113371A
    2-Methylcitric acid trisodium
    2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
    2-Methylcitric acid trisodium
  • HY-W016628
    L-Gulono-1,4-lactone
    		99.70%
    L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
    L-Gulono-1,4-lactone
  • HY-W251708
    AHR 10240
    AHR 10240, a cyclic amide, is a metabolite of Bromfenac (HY-B1888). AHR 10240 can be used for analgesia research
    AHR 10240
  • HY-B1899S
    Taurodeoxycholic acid-d5
    Taurodeoxycholic acid-d5 is the deuterium labeled Taurodeoxycholic acid (HY-B1899). Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD).
    Taurodeoxycholic acid-d<sub>5</sub>
  • HY-N1420AR
    Rhamnose monohydrate (Standard)
    Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas.
    Rhamnose monohydrate (Standard)
  • HY-P2877
    Tannase
    Tannase, also known as tanninyl hydrolase, is an enzyme that can hydrolyze ester bonds and tannic acid side bonds, releasing glucose and gallic acid, and is outstanding in clarifying wine and fruit juice.
    Tannase
  • HY-N8349
    19,20-Epoxycytochalasin D
    19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity.
    19,20-Epoxycytochalasin D
  • HY-76504
    2,6-Dimethoxybenzoic acid
    		99.99%
    2,6-Dimethoxybenzoic acid is a member of organic compounds known as o-methoxybenzoic acids and derivatives.
    2,6-Dimethoxybenzoic acid
  • HY-N1423B
    Glycocholic acid hydrate
    Glycocholic acid hydrate is an endogenous metabolite.
    Glycocholic acid hydrate
  • HY-129770
    D-Methionine sulfoxide
    		98.74%
    D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing.
    D-Methionine sulfoxide
  • HY-P2818C
    Alkaline phosphatase, microorganism
    Alkaline phosphatase, microorganism is a membrane-bound glycoprotein. It can hydrolyze monophosphate esters at alkaline pH, releasing inorganic phosphate. Alkaline phosphatase, microorganism is also capable of dephosphorylating proteins, and the balance between protein phosphorylation and dephosphorylation plays a key role in regulating various cellular functions. Alkaline phosphatase, microorganism can regulate cell proliferation and differentiation.
    Alkaline phosphatase, microorganism
  • HY-N0229S1
    L-Alanine-1-13C
    		99.0%
    L-Alanine-1-13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1-<sup>13</sup>C
Cat. No. Product Name / Synonyms Application Reactivity