2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    NF-κB
  4. MALT1
  5. MALT1 Degrader

MALT1 Degrader

MALT1 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-173097
    (S,R,S)-AHPC-Boc derivative 1
    		Degrader
    (S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).