2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  4. HSP
  5. HSP Ligand

HSP Ligand

HSP Isoform Comparison

HSP Ligands (3):

Cat. No. Product Name Effect Purity
  • HY-174476
    HSP90i
    		Ligand
    HSP90i is the ligand for HSP90 and can be used for synthesis of LYTACs, such as dPDL1-4 (HY-174468).
  • HY-174799
    HSP90i-COCH2CH2-PEG4-NHBoc
    		Ligand
    HSP90i-COCH2CH2-PEG4-NHBoc is a conjugate of the HSP90 Ligand (HY-174476) and the linker (HY-W021787). HSP90i-COCH2CH2-PEG4-NHBoc can be used for synthesis of LYTACs, such as dPDL1-4 (HY-174468).
  • HY-174468
    dPDL1-4
    		Ligand
    dPDL1-4 is a potent and selective eHSPTAC eHSP90 PD-L1 degrader with DC50s of 7.77μM and 6.52 μM in HeLa and B16F10 cells. dPDL1-4 bridges eHSP90 with the target protein, inducing lysosomal degradation. dPDL1-4 can degrade PD-L1 significantly and inhibits tumor growth. dPDL1-4 can be used for the study of cervical cancer and melanoma. ((Pink: eHSP90 ligand (HY-174476); Blue: PD-L1 ligand (HY-116274); Black: Linker (HY-W021787); HSP ligand + linker: HY-174799)).