2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  4. HSP

HSP

Heat shock proteins

HSP

Related Products

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HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

HSP Isoform Specific Products:

HSP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0830S18
    Palmitic acid-d
    		Activator
    Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
    Palmitic acid-d
  • HY-N0830S
    Palmitic acid-1,2,3,4-13C4
    		Activator
    Palmitic acid-1,2,3,4-13C4 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].
    Palmitic acid-1,2,3,4-<sup>13</sup>C<sub>4</sub>
  • HY-155113
    PROTAC Hsp90α degrader 1
    		Degrader
    PROTAC Hsp90α degrader 1 (Compound X10g) is a selective PROTAC Hsp90α degrader. PROTAC Hsp90α degrader 1 can be used for breast cancer research. PROTAC Hsp90α degrader 1 inhibits the proliferation of MDA-MB-231, MDA-MB-468, MCF-7, MX-1 cells with IC50s of 51.48 μM, 16.46 μM, 8.93 μM, 11.95 μM respectively.
    PROTAC Hsp90α degrader 1
  • HY-N6679A
    10,11-Dehydrocurvularin
    		Activator 99.75%
    10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.
    10,11-Dehydrocurvularin
  • HY-152184
    SEW84
    		Inhibitor 99.73%
    SEW84
  • HY-153588
    HSP90-IN-22
    		Inhibitor ≥98.0%
    HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.
    HSP90-IN-22
  • HY-133571
    Aminohexylgeldanamycin
    		Inhibitor 99.56%
    Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities.
    Aminohexylgeldanamycin
  • HY-10213A
    SNX-5422 mesylate
    		Inhibitor
    SNX-5422 Mesylate (PF-04929113 Mesylate), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM.
    SNX-5422 mesylate
  • HY-115781
    DN401
    		Inhibitor ≥99.0%
    DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities.
    DN401
  • HY-119906
    Conglobatin
    		Inhibitor
    Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo.
    Conglobatin
  • HY-N6249
    Feretoside
    		Activator 98.69%
    Feretoside, a phenolic compound extracted from the barks of E. ulmoides, is a HSP inducer which act as cytoprotective agent.
    Feretoside
  • HY-153911
    H2-Gamendazole
    		98.20%
    H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research.
    H2-Gamendazole
  • HY-122876
    KUNB31
    		Inhibitor 98.9%
    KUNB31 is a selective inhibitor of SP90β with an Kd value of 0.18 μM.
    KUNB31
  • HY-11038D
    Zelavespib formic
    		Inhibitor
    Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells.
    Zelavespib formic
  • HY-P990805
    Anti-Human/Mouse GRP78 Antibody (C38)
    		Inhibitor
    Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b kappa in vivo mouse antibody, targeting to GRP78. The recommend isotype control of Anti-Human/Mouse GRP78 Antibody (C38): Mouse IgG2b kappa, Isotype Control (HY-P99982).
    Anti-Human/Mouse GRP78 Antibody (C38)
  • HY-106443
    Arimoclomol
    		Activator
    Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann–Pick disease type C.
    Arimoclomol
  • HY-170944
    BAG3/HSP70-IN-1
    		Inhibitor
    BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3/HSP70 dual modulator. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC50 of 49.46 μM. BAG3/HSP70-IN-1 induces Apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity.
    BAG3/HSP70-IN-1
  • HY-151137
    HSP90/mTOR-IN-1
    		Inhibitor
    HSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC50 values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer.
    HSP90/mTOR-IN-1
  • HY-147039
    BOLD-100 free base
    		Inhibitor
    BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.
    BOLD-100 free base
  • HY-113916
    Onalespib lactate
    		Inhibitor
    Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an Kd value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC).
    Onalespib lactate
Cat. No. Product Name / Synonyms Application Reactivity
HSP Isoform Comparison

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