2. Signaling Pathways
  3. Anti-infection
  4. HBV

HBV

Hepatitis B virus

HBV

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HBV (Hepatitis B virus), abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168045
    HBV-IN-48
    		Inhibitor
    HBV-IN-48 is an HBV inhibitor. HBV-IN-48 has antiviral activity against HBV in HepDE19 cells, with an EC50 value of 0.005 μM. HBV-IN-48 can reduce serum HBV DNA levels in mouse models of HBV infection.
    HBV-IN-48
  • HY-N0054R
    Osthole (Standard)
    		Inhibitor
    Osthole (Standard) is the analytical standard of Osthole. This product is intended for research and analytical applications. Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
    Osthole (Standard)
  • HY-145871
    BA38017
    		Inhibitor
    BA38017 is a potent HBV core protein assembly modulator. BA38017 inhibits HBV replication with an EC50 of 0.20 μM.
    BA38017
  • HY-163124
    HBV-IN-43
    HBV-IN-43 (compound 5832) is a potent inhibitor of HBV.
    HBV-IN-43
  • HY-147266A
    Elebsiran
    		Inhibitor
    Elebsiran is a siRNA against hepatitis B and D virus infections .
    Elebsiran
  • HY-126033
    Sophoranol
    		Inhibitor
    Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL.
    Sophoranol
  • HY-P4049
    HBV Seq1 aa:63-71
    HBV Seq1 aa:63-71 is the fragment of hepatitis B virus (HBV).
    HBV Seq1 aa:63-71
  • HY-N6939R
    Pseudolaric Acid B (Standard)
    		Inhibitor
    Pseudolaric Acid B (Standard) is the analytical standard of Pseudolaric Acid B. This product is intended for research and analytical applications. Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2.
    Pseudolaric Acid B (Standard)
  • HY-Y0073R
    4-Hydroxyacetophenone (Standard)
    		Inhibitor
    4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer.
    4-Hydroxyacetophenone (Standard)
  • HY-156272
    HBV-IN-41
    		Inhibitor
    HBV-IN-41 (compound 45) is a potent and orally active Hepatitis B Virus (HBV) inhibitor, with an EC50 of 0.027μM.
    HBV-IN-41
  • HY-13623S1
    Entecavir-13C2,15N
    		Inhibitor
    Entecavir-13C2,15N (BMS200475-13C2,15N; SQ34676-13C2,15N) is a 13C- and 15N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
    Entecavir-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-B0277AR
    Vidarabine phosphate (Standard)
    		Inhibitor
    Vidarabine phosphate (Standard) is the analytical standard of Vidarabine phosphate. This product is intended for research and analytical applications. Vidarabine phosphate (Ara-AMP), an antiviral agent, inhibits chronic HBV infection[1][2]. Vidarabine phosphate also against herpes simplex and varicella zoster viruses[3].
    Vidarabine phosphate (Standard)
  • HY-109969
    Z060228
    		Inhibitor
    Z060228 is a capsid-targeting anti-HBV agent that inhibits HBV DNA replication in the supernatant of the HepG2.2.15 cell.
    Z060228
  • HY-127122
    Valtorcitabine dihydrochloride
    		Inhibitor
    Valtorcitabine dihydrochloride is a prodrug of L-deoxycytidine and also is an HBV inhibitor.
    Valtorcitabine dihydrochloride
  • HY-N8168
    LPRP-Et-97543
    		Inhibitor
    LPRP-Et-97543 is a potent anti-HBV agent. LPRP-Et-97543 reduces Core, S, and preS but not X promoter activities. LPRP-Et-97543 can be used for acute and chronic HBV infections research.
    LPRP-Et-97543
  • HY-106235
    LB80317
    		Inhibitor
    LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment.
    LB80317
  • HY-N10404
    Junceellolide C
    		Inhibitor
    Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent.
    Junceellolide C
  • HY-148782
    HBV-IN-31
    		Inhibitor
    HBV-IN-31 is a potent cccDNA (covalently closed circular DNA) inhibitor. HBV-IN-31 shows anti-HBV activity with an IC50 value of 0.13 µM for HBsAg. HBV-IN-31 inhibits cell growth.
    HBV-IN-31
  • HY-123767
    HEC72702
    		Inhibitor
    HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers.
    HEC72702
  • HY-145638
    Xalnesiran
    		Inhibitor
    Xalnesiran is siRNA for the treatment of chronic hepatitis B (HBV).
    Xalnesiran
Cat. No. Product Name / Synonyms Application Reactivity