2. Signaling Pathways
  3. Anti-infection
  4. HBV

HBV

Hepatitis B virus

HBV

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HBV (Hepatitis B virus), abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-109195
    Vebicorvir
    		Inhibitor 99.73%
    Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM.
    Vebicorvir
  • HY-P99608
    Exbivirumab
    		Inhibitor
    Exbivirumab is a monoclonal antibody directed against highly conserved HBsAg epitopes. Exbivirumab enhances the antiviral activity of hepatitis B immunoglobulin (HBIG). Exbivirumab combined with Libivirumab (HY-P99703) decreases circulating HBsAg and hepatitis B virus (HBV) DNA levels in a chronically infected chimpanzee. Exbivirumab can be used for HBV re-infection in liver transplant.
    Exbivirumab
  • HY-148560B
    cis-ccc_R08
    		Inhibitor 99.61%
    cis-ccc_R08 (compound 1) is a flavonoid derivative that can be used in the study of hepatitis B virus (HBV) infection. cis-ccc_R08 is a cccDNA (covalently closed circular DNA) inhibitor.
    cis-ccc_R08
  • HY-107902
    RIG-1 modulator 1
    		Inhibitor 99.54%
    RIG-1 modulator 1 (Compound of claim 13) is an anti-viral compound which can be used against viral infections including influenza virus, HBV, HCV and HIV.
    RIG-1 modulator 1
  • HY-B0250R
    Lamivudine (Standard)
    		Inhibitor
    Lamivudine (Standard) is the analytical standard of Lamivudine. This product is intended for research and analytical applications. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
    Lamivudine (Standard)
  • HY-153797
    Dox-btn2
    		Activator
    Dox-btn2 is a biotin labeled Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm.
    Dox-btn2
  • HY-123336
    Schisantherin C
    		Inhibitor 99.66%
    Schisantherin C exhibits anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7% at 50μg/mL.
    Schisantherin C
  • HY-N5086
    Picroside IV
    		Inhibitor 99.08%
    Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820). Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects.
    Picroside IV
  • HY-137453
    Tenofovir amibufenamide
    		Inhibitor 99.67%
    Tenofovir amibufenamide (HS-10234), a Tenofovir prodrug, is an orally active antiviral agent. Tenofovir amibufenamide inhibits HBV, and can be used for chronic hepatitis B (CHB) study.
    Tenofovir amibufenamide
  • HY-114314
    BA-53038B
    		Inhibitor 98.73%
    BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.
    BA-53038B
  • HY-79631
    (Tetrahydro-2H-pyran-4-yl)methanol
    		Inhibitor 99.96%
    (Tetrahydro-2H-pyran-4-yl)methanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    (Tetrahydro-2H-pyran-4-yl)methanol
  • HY-148348
    AB-836
    		Inhibitor 99.13%
    AB-836 is an orally active HBV capsid inhibitor. AB-836 inhibits viral replication by interacting with HBV core protein.
    AB-836
  • HY-P3601
    Brain Derived Basic Fibroblast Growth Factor (1-24)
    		Inhibitor 98.01%
    Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research.
    Brain Derived Basic Fibroblast Growth Factor (1-24)
  • HY-N10543
    5-O-(E)-p-Coumaroylquinic acid
    		Inhibitor 99.86%
    5-O-(E)-p-Coumaroylquinic acid, a quinic acid derivative, is a potent phytochemical agent against hepatitis B virus.
    5-O-(E)-p-Coumaroylquinic acid
  • HY-169993
    ALG-000184
    		Inhibitor 99.69%
    ALG-000184, a prodrug of the potent Hhepatitis B virus (HBV) capsid assembly modulator ALG-001075, has the potential for the research of HBV infection research.
    ALG-000184
  • HY-100028
    AT-130
    		Inhibitor 98.39%
    AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells.
    AT-130
  • HY-P99703
    Libivirumab
    		Inhibitor 98.27%
    Libivirumab (17.1.41) is a human anti-HBV monoclonal antibody. Libivirumab shows neutralization activity with IC50s of 35, 130 ng/mL for HBsAg, HBeAg, respectively.
    Libivirumab
  • HY-121513
    Torcitabine
    		Inhibitor 99.61%
    Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment.
    Torcitabine
  • HY-106233B
    Tiviciclovir hydrochloride
    		Inhibitor 99.36%
    Tiviciclovir (AM188) hydrochloride is an antiviral guanosine analog and a hepatitis B virus inhibitor.
    Tiviciclovir hydrochloride
  • HY-N0680S1
    Thiamine-d3 hydrochloride
    		Inhibitor 98.92%
    Thiamine-d3 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
    Thiamine-d<sub>3</sub> hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity