2. Signaling Pathways
  3. Anti-infection
  4. HBV

HBV

Hepatitis B virus

HBV

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HBV (Hepatitis B virus), abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112142A
    (Rac)-AB-423
    		Inhibitor
    (Rac)-AB-423 (DVR-23) is an anti-HBV candidate compound with promising anti-HBV activity. (Rac)-AB-423 showed no induction of CYP1A2, CYP3A4, or CYP2B6 enzyme activity at high concentrations. (Rac)-AB-423 exhibited desirable pharmacokinetic properties, enabling good systemic exposure and high oral bioavailability. (Rac)-AB-423 achieved more than 2 log viral load reduction in the hydrodynamic injection (HDI) HBV mouse model.
    (Rac)-AB-423
  • HY-124364
    RO6889678
    		Inhibitor
    RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation.
    RO6889678
  • HY-N2988
    Schisanwilsonin C
    		Inhibitor
    Schisanwilsonin C (Arisanschinin K) shows anti-HBV activity.
    Schisanwilsonin C
  • HY-13623C
    (1R,3S,4R)-ent-Entecavir
    		Control
    (1R,3S,4R)-ent-Entecavir ((1R,3S,4R)-ent-BMS200475; (1R,3S,4R)-ent-SQ34676) can be used to synthesize PROTAC targets to degrade deoxyribonucleic acid (DNA) polymerase.
    (1R,3S,4R)-ent-Entecavir
  • HY-P4048
    HBV Seq1 aa:93-100
    HBV Seq1 aa:93-100 is a hepatitis B virus (HBV) core antigen 93-100 peptide fragment.
    HBV Seq1 aa:93-100
  • HY-149392
    HBV-IN-35
    		Inhibitor
    HBV-IN-35 (Compound 88) is a HBV inhibitor. HBV-IN-35 has anti-HBV activities in mouse and human hepatocytes (EC50: 100 nM and 400 nM respectively).
    HBV-IN-35
  • HY-148783
    HBV-IN-32
    		Inhibitor
    HBV-IN-32 is a potent cccDNA (covalently closed circular DNA) inhibitor. HBV-IN-32 shows anti-HBV activity with an IC50 value of 0.14 µM for HBsAg. HBV-IN-32 inhibits cell growth.
    HBV-IN-32
  • HY-107315
    Alisol F 24-acetate
    		Inhibitor
    Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research.
    Alisol F 24-acetate
  • HY-N0820R
    Catalpol (Standard)
    		Inhibitor
    Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects.
    Catalpol (Standard)
  • HY-145872
    HBV-IN-20
    		Inhibitor
    HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).
    HBV-IN-20
  • HY-162327
    PROTAC PAPD5 degrader 1
    		Inhibitor
    PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo, with IC50 and CC50 of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells.
    PROTAC PAPD5 degrader 1
  • HY-N4168A
    Neochlorogenic acid methyl ester
    		Inhibitor
    Neochlorogenic acid methyl ester (5-O-Caffeoylquinic acid methyl ester) is an HBV inhibitor. Neochlorogenic acid methyl ester can be isolated from L. japonica flower buds with potent HBV inhibitory activity.
    Neochlorogenic acid methyl ester
  • HY-159987
    AB-161
    		Inhibitor
    AB-161 is an orally active HBV RNA destabilizer and a PAPD5/7 inhibitor, with its primary action focused in the liver. AB-161 treats Hepatitis B Virus (HBV) infection by lowering the levels of Hepatitis B surface antigen (HBsAg), with an EC50 value of 2.2 nM for HBsAg. AB-161 can be used in the field of HBV infection research.
    AB-161
  • HY-113648
    LP10
    		Inhibitor
    LP10 is a non-azole CYP51 inhibitor with activity against Trypanosoma cruzi infection. Treatment with LP10 blocks the 14α-demethylation step, leading to disruption of the parasite cell membrane and ultimately triggering the death of important clinically relevant amoeba stages.
    LP10
  • HY-116154
    Metacavir
    		Inhibitor
    Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity.
    Metacavir
  • HY-122209
    DVR-01
    		Inhibitor
    DVR-01 is a HBV inhibitor with EC50 values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively. DVR-01 shows antiviral activity against drug-resistant HBV mutants with EC50s of 2.403-3.273 μM. DVR-01 can be used for the research of HBV infection and related diseases.
    DVR-01
  • HY-P4044
    HBV Seq2 aa:28-39
    HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules.
    HBV Seq2 aa:28-39
  • HY-107026
    Lagociclovir valactate
    		Inhibitor
    Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent.
    Lagociclovir valactate
  • HY-W616313S
    Cyprosulfamide-d4
    		Inhibitor
    Cyprosulfamide-d4 is deuterium labeled Cyprosulfamide. Cyprosulfamide serves as a herbicide that safeguards plants against salinity stress while promoting vigorous growth, including the development of new tillers and early flowering.
    Cyprosulfamide-d<sub>4</sub>
  • HY-W351380
    (-)-Anicyphos
    		Inhibitor
    (-)-Anicyphos is a chiral catalyst with the activity of promoting the selectivity of specific reactions. (-)-Anicyphos is often used to synthesize complex chiral molecules in organic synthesis and shows excellent catalytic performance. By adjusting the reaction conditions, (-)-Anicyphos can significantly improve the stereospecificity of the product, providing an effective strategy for compound development.
    (-)-Anicyphos
Cat. No. Product Name / Synonyms Application Reactivity