2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W775186
    Tolprocarb
    		Inhibitor 99.72%
    Tolprocarb is an oomyces fungicide, which has a strong inhibitory effect on rice blast fungus Magnaporthe grisea by inhibiting polyketide synthase in melanin synthesis pathway .
    Tolprocarb
  • HY-124701
    Filastatin
    		Inhibitor 99.27%
    Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect.
    Filastatin
  • HY-B2051
    Triclopyr
    		99.80%
    Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity.
    Triclopyr
  • HY-N2105
    (-)-Dicentrine
    		Inhibitor 99.80%
    (-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and Candida albicans.
    (-)-Dicentrine
  • HY-B0914R
    10-Undecenoic acid (Standard)
    		Inhibitor
    10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
    10-Undecenoic acid (Standard)
  • HY-N1579R
    Pyrogallol (Standard)
    		Inhibitor
    Pyrogallol (Standard) is the analytical standard of Pyrogallol. This product is intended for research and analytical applications. Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.
    Pyrogallol (Standard)
  • HY-W653962
    Triclosan-13C6
    		Inhibitor 99.51%
    Triclosan-13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.
    Triclosan-<sup>13</sup>C<sub>6</sub>
  • HY-B1151S
    Climbazole-d4
    		Inhibitor 99.91%
    Climbazole-d4 is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
    Climbazole-d<sub>4</sub>
  • HY-W028684
    2,4′-Dichloroacetanilide
    		Inhibitor 99.68%
    2,4′-Dichloroacetanilide is a fungistatic agent. 2,4′-Dichloroacetanilide inhibits T. asteroides with a MIC value of 6.25 μg/mL.
    2,4′-Dichloroacetanilide
  • HY-Y0729
    4-Chlorocinnamic acid
    		Inhibitor 99.98%
    4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth.
    4-Chlorocinnamic acid
  • HY-P2092
    Cyclo(L-leucyl-L-tryptophyl)
    		Inhibitor
    Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand.
    Cyclo(L-leucyl-L-tryptophyl)
  • HY-W115529
    Geranic acid
    		Inhibitor
    Geranic acid is a monoterpenemainly used in flavor, fragrance, cosmetics and agro-industries. In vitro studies show that geranic acid exhibits strong inhibitory activity against Fusarium graminearum and Colletotrichum graminicola, the two main fungal pathogens of maize. It also exhibits antitumor activity.
    Geranic acid
  • HY-164620
    Antifungal agent 112
    		Inhibitor 99.50%
    Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candida albicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively.
    Antifungal agent 112
  • HY-133719
    Fenfuram
    		Inhibitor 99.91%
    Fenfuram is an antifungal agent with an EC50 of 6.18 mg/mL against R. solani. Fenfuram can be used in anti-infective research.
    Fenfuram
  • HY-17006S
    Caspofungin-d4 diacetate
    Caspofungin-d4 (acetate) is the deuterium labeled Caspofungin diacetate. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
    Caspofungin-d<sub>4</sub> diacetate
  • HY-N12343
    Tetrahydrorhombifoline
    		Inhibitor
    Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities.
    Tetrahydrorhombifoline
  • HY-W706180
    (±)-Triadimefon-d4
    		Inhibitor 99.47%
    (±)-Triadimefon-d4 is deuterium labeled Triadimefon. Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
    (±)-Triadimefon-d<sub>4</sub>
  • HY-B2033R
    Pyrimethanil (Standard)
    		Inhibitor
    Pyrimethanil (Standard) is the analytical standard of Pyrimethanil. This product is intended for research and analytical applications. Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
    Pyrimethanil (Standard)
  • HY-W009335
    Iodopropynyl butylcarbamate
    		Inhibitor
    Iodopropynyl butylcarbamate (IPBC) is a potent fungicide and preservative, which has been used in the paints, coatings, wood preservatives, personal care, and cosmetics industries.
    Iodopropynyl butylcarbamate
  • HY-B0842S
    Thiophanate-methyl-d6
    		Inhibitor
    Thiophanate-methyl-d6 is the deuterium labeled Thiophanate-methyl. Thiophanate-Methyl is a systematic fungicide.
    Thiophanate-methyl-d<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity