2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121884
    Spiroxamine
    		Inhibitor 99.94%
    Spiroxamine is a fungicide that can be used to kill grapes with less residue.
    Spiroxamine
  • HY-N2612
    O-Methyldauricine
    		Inhibitor
    O-Methyldauricine ((-)-O-Methyldauricine) is an alkaloid with benzylisoquinoline group, which can be separated from P. ophthalmicus. O-Methyldauricine has antibacterial activity.
    O-Methyldauricine
  • HY-139903
    Antifungal agent 18
    		Inhibitor 98.08%
    Antifungal agent 18 is a novel antifungal agent for the research of fungal infection.
    Antifungal agent 18
  • HY-N3570
    Cerebroside B
    		Inhibitor ≥98.0%
    Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice.
    Cerebroside B
  • HY-N7516
    4'-Hydroxy-2,4-dimethoxychalcone
    		Inhibitor 99.76%
    4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity.
    4'-Hydroxy-2,4-dimethoxychalcone
  • HY-108012
    ME1111
    		Inhibitor 99.95%
    ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.
    ME1111
  • HY-W014316
    5-Bromo-5-nitro-1,3-dioxane
    		Inhibitor 99.89%
    5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol.
    5-Bromo-5-nitro-1,3-dioxane
  • HY-B2144E
    Chitosan (≥90% deacetylated, Low viscosity,<200mPa.s)
    		Inhibitor
    Chitosan (Deacetylated chitin) (≥90% deacetylated, Low viscosity,<200mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi.
    Chitosan (≥90% deacetylated, Low viscosity,<200mPa.s)
  • HY-B0105S1
    Ketoconazole-d4
    		Inhibitor 99.63%
    Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole-d<sub>4</sub>
  • HY-117245
    Pallidol
    		Inhibitor
    Pallidol is a potent and selective singlet oxygen quencher. Pallidol shows antioxidant and antifungal activities.
    Pallidol
  • HY-Y0569B
    D-Gluconic acid calcium hydrate
    		Inhibitor ≥98.0%
    D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.
    D-Gluconic acid calcium hydrate
  • HY-W014589R
    2,4-Di-tert-butylphenol (Standard)
    		Inhibitor
    2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol (HY-W014589). This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities, and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of pharmaceuticals and fragrances.
    2,4-Di-tert-butylphenol (Standard)
  • HY-108938
    SDZ285428
    		Inhibitor 98.00%
    SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h).
    SDZ285428
  • HY-134655
    D75-4590
    		Inhibitor 99.14%
    D75-4590, a pyridobenzimidazole derivative and a β-1,6-glucan synthesis inhibitor, possesses antifungal activity.
    D75-4590
  • HY-P1508A
    Bactenecin TFA
    		Inhibitor 98.42%
    Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.
    Bactenecin TFA
  • HY-N11772
    Mutanocyclin
    		Inhibitor 99.94%
    Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse.
    Mutanocyclin
  • HY-N10418
    Isorhapontin
    		Inhibitor 98.42%
    Isorhapontin is an antifungal agent. Isorhapontin inhibits the hydrolytic activity of Trichoderma cellobiohydrolase I (CBH I) with a Ki of 57.2 μM. Isorhapontin also inhibits the activity of Trichoderma endoglucanase I.
    Isorhapontin
  • HY-W007355S1
    Skatole-d8
    		Inhibitor 98.50%
    Skatole-d8 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
    Skatole-d<sub>8</sub>
  • HY-N6952R
    Geraniol (Standard)
    		Inhibitor
    Geraniol (Standard) is the analytical standard of Geraniol. This product is intended for research and analytical applications. Geraniol, an olefinic terpene, was found to inhibit growth of Candida albicans and Saccharomyces cerevisiae strains.
    Geraniol (Standard)
  • HY-B2067
    Cymoxanil
    		Inhibitor 99.55%
    Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora.
    Cymoxanil
Cat. No. Product Name / Synonyms Application Reactivity