2. Signaling Pathways
  3. Anti-infection
  4. Filovirus

Filovirus

Filovirus

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Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).

The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Filovirus Isoform Specific Products:

Filovirus Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115412
    Vorinostat-d5
    		Inhibitor ≥99.0%
    Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
    Vorinostat-d5
  • HY-P99784
    Porgaviximab
    		Inhibitor 98.00%
    Porgaviximab is a monoclonal antibody that can be used Ebola infection research.
    Porgaviximab
  • HY-10221R
    Vorinostat (Standard)
    		Inhibitor
    Vorinostat (Standard) is the analytical standard of Vorinostat. This product is intended for research and analytical applications. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
    Vorinostat (Standard)
  • HY-160877
    EBOV-IN-2
    EBOV-IN-2 (Compound 2) is an inhibitor of Ebola virus (EBOV) with IC50 values of 0.37 μM and 2.54 μM against Ebola virus glycoprotein pseudotype virus (pEBOV) and African swine fever virus (ASFV), respectively.
    EBOV-IN-2
  • HY-146813
    EBOV/MARV-IN-2
    		Inhibitor
    EBOV/MARV-IN-2 (compound 13) is an Ebolavirus (EBOV, IC50=0.9 μM) and Marburg virus (MARV, IC50=2.7 μM) inhibitor.
    EBOV/MARV-IN-2
  • HY-160881
    EBOV-IN-6
    EBOV-IN-6 (compound 19) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC50 value of 10 μM.
    EBOV-IN-6
  • HY-160883
    EBOV-IN-8
    		Inhibitor
    EBOV-IN-8 (Compound 30) inhibits Ebola pseudotyped virus (pEBOV) infection with an IC50 of 62.1% at 10 μM.
    EBOV-IN-8
  • HY-123266
    D011-2120
    		Inhibitor
    D011-2120 functions as an antiviral agent by inhibiting microtubule polymerization, disrupting the Golgi complex, and preventing viral trafficking to the plasma membrane during the virus egress process.
    D011-2120
  • HY-146883
    As-358
    		Inhibitor
    As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM.
    As-358
  • HY-N2076
    Cephaeline hydrochloride
    		Inhibitor
    Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
    Cephaeline hydrochloride
  • HY-113761
    ASN03576800
    		Inhibitor 99.61%
    ASN03576800 could be a potent inhibitor for Ebola virus matrix protein VP40 in process of viral assembly and budding process. ASN03576800 occupies the RNA binding region of VP40.
    ASN03576800
  • HY-160880
    EBOV-IN-5
    		Inhibitor
    EBOV-IN-5 (compound 14) is an antiviral agent that inhibits Ebola virus (EBOV) infection. EBOV-IN-5 inhibits the binding of the EBOV glycoprotein EBOV-GPcl to NPC1, an indispensable host receptor required for viral fusion/entry.
    EBOV-IN-5
  • HY-119293A
    K777 tosylate
    		Inhibitor
    K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively.
    K777 tosylate
  • HY-146814
    EBOV/MARV-IN-3
    		Inhibitor
    EBOV/MARV-IN-3 (compound 32) is a potent EBOV and MARV inhibitor with IC50 values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity.
    EBOV/MARV-IN-3
  • HY-160879
    EBOV-IN-4
    		Inhibitor
    EBOV-IN-4 (compound 12), a benzothiazepine, is a potent Ebola virus (EBOV) inhibitor with 64.9% inhibitory for EBOV-GP-pseudotype virus (pEBOV) with 10 μM. EBOV-IN-4 is inactive with ASFV.
    EBOV-IN-4
  • HY-W143403A
    (-)-Isopinocampheol
    		Inhibitor
    (-)-Isopinocampheol (l-Isopinocampheol) is a compound with anti-filovirus activity. Its derivatives inhibit infection by Ebola virus and Marburg virus, possibly through binding to surface glycoproteins. It also has lysosomal affinity.
    (-)-Isopinocampheol
  • HY-146883A
    As-358 hydrochloride
    		Inhibitor
    As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.
    As-358 hydrochloride
  • HY-160882
    EBOV-IN-7
    EBOV-IN-7 (compound 26) is an inhibitor of the Ebola virus EBOV with an IC50 of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). EBOV-IN-7 has inhibitory effects on cancer cells and inhibits the EBOV-GPcl/NPC1 interaction.
    EBOV-IN-7
  • HY-146815
    CP19
    		Inhibitor
    CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC50s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity.
    CP19
  • HY-160878
    EBOV-IN-3
    		Inhibitor
    EBOV-IN-3 (compound 9) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC50 value of 0.37 μM.
    EBOV-IN-3
Filovirus Isoform Comparison

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