2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Elastase

Elastase

Elastase

Related Products

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Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase. Elastase can not only cleave the important connective tissue protein elastin, but also facilitate the degradation of the extracellular matrix such as fibronectin; laminin; collagens III, IV, and VI; and proteoglycans.

Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation, and atherosclerosis.

Elastase Related Products (79):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19908B
    (R)-BAY-85-8501
    		Control 99.09%
    (R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM.
    (R)-BAY-85-8501
  • HY-103445
    SSR69071
    		Inhibitor ≥98.0%
    SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury. SSR69071 displays a higher affinity for human elastase (Ki=0.0168 nM) than for rat (Ki=3 nM), mouse (Ki=1.8 nM), and rabbit (Ki= 58 nM) elastases.
    SSR69071
  • HY-N1235
    Skullcapflavone I
    		Inhibitor
    Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a.
    Skullcapflavone I
  • HY-15652
    Freselestat
    		Inhibitor 99.68%
    Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity.
    Freselestat
  • HY-155414
    Neutrophil elastase inhibitor 5
    		Inhibitor
    Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases.
    Neutrophil elastase inhibitor 5
  • HY-111457
    BAY-677
    		Control 98.02%
    BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
    BAY-677
  • HY-P4669
    LM-030
    		Inhibitor
    LM-030 (BPR277) is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC50s of 6 nM and 55 nM, respectively(Example 4). LM-030 can be used for the study of Netherton syndrome.
    LM-030
  • HY-P3293
    Lonodelestat
    		Inhibitor 99.59%
    Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF).
    Lonodelestat
  • HY-19406
    AE-3763
    		Inhibitor 99.82%
    AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
    AE-3763
  • HY-U00256
    ZD8321
    		Inhibitor
    ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM.
    ZD8321
  • HY-100240
    Lodelaben
    		Inhibitor
    Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
    Lodelaben
  • HY-15652A
    Freselestat quarterhydrate
    		Inhibitor ≥99.0%
    Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity.
    Freselestat quarterhydrate
  • HY-N8164
    19α-Hydroxyasiatic acid
    		Inhibitor 99.56%
    19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity.
    19α-Hydroxyasiatic acid
  • HY-15651A
    Alvelestat tosylate
    		Inhibitor
    Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM.
    Alvelestat tosylate
  • HY-100397R
    Elastatinal (Standard)
    		Inhibitor
    Phenethyl acetate (Standard) is the analytical standard of Phenethyl acetate. This product is intended for research and analytical applications. Phenethyl acetate (Phenethyl alcohol) is a natural product.
    Elastatinal (Standard)
  • HY-P4346
    MeOSuc-Ala-Ala-Pro-Met-AMC
    MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases.
    MeOSuc-Ala-Ala-Pro-Met-AMC
  • HY-120876
    L-680833
    		Inhibitor
    L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases.
    L-680833
  • HY-P5374
    MeOSuc-AAPV-AFC
    MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)
    MeOSuc-AAPV-AFC
  • HY-P5459
    Elafin(human)
    		Inhibitor
    Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus.
    Elafin(human)
  • HY-P3648
    Ala-Ala-Pro-Val-chloromethylketone
    		Inhibitor
    Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases.
    Ala-Ala-Pro-Val-chloromethylketone