Elastase Inhibitor

Elastase Inhibitors (67):

Cat. No.	Product Name	Effect	Purity

HY-17443

Sivelestat	Inhibitor	99.34%
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

HY-15651

Alvelestat	Inhibitor	99.87%
Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC₅₀ value of 7.9 nM, a K_i value of 9.4 nM and a K_d value of 9.5 nM.

HY-75957

DMP 777	Inhibitor	99.82%
DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

HY-15891A

GW311616 hydrochloride	Inhibitor	98.84%
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM.

HY-136705

MeO-Suc-Ala-Ala-Pro-Ala-CMK	Inhibitor
MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20.3 μM. MeO-Suc-Ala-Ala-Pro-Ala-CMK can inhibit the hydrolysis of substrates such as elastin in lung tissue by HNE. MeO-Suc-Ala-Ala-Pro-Ala-CMK can be used in the research of related diseases such as chronic obstructive pulmonary disease (COPD).

HY-120039A

(S)-MDL-101146	Inhibitor
(S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a K_i value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis.

HY-174380

DPP-1-IN-1	Inhibitor
DPP-1-IN-1 (Compound 14) is an orally active inhibitor of Cathepsin C (also known as Dipeptidyl peptidase I) with an IC₅₀ of 5.31 nM. DPP-1-IN-1 can inhibit the activity of Cathepsin C downstream Neutrophil elastase in neutrophils. DPP-1-IN-1 can be used in the research of inflammatory diseases.

HY-17443B

Sivelestat sodium tetrahydrate	Inhibitor	99.90%
Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

HY-17443A

Sivelestat sodium	Inhibitor	99.77%
Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

HY-19908

BAY-85-8501	Inhibitor	99.72%
BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC₅₀ of 65 pM.

HY-15891

GW311616	Inhibitor	99.30%
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM.

HY-111457A

BAY-678	Inhibitor	99.59%
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

HY-19254

ZD-0892	Inhibitor
ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with K_is of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

HY-136888

MeOSuc-AAPV-CMK	Inhibitor	99.73%
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase.

HY-P3293A

Lonodelestat TFA	Inhibitor	98.20%
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF).

HY-19269

FK706	Inhibitor	99.12%
FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC₅₀ of 83 nM and a K_i of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC₅₀s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect.

HY-N2395

Chrysophanol 8-O-glucoside	Inhibitor	99.10%
Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity.

HY-N6876

Secologanoside	Inhibitor	≥99.0%
Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC₅₀ of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.

HY-W104758

Elastase-IN-3	Inhibitor	99.56%
Elastase-IN-3 (Compound 2i) is an Elastase inhibitor of Pseudomonas aeruginosa. Elastase-IN-3 inhibits the quorum sensing system of Pseudomonas aeruginosa by targeting the LasR protein (K_D value of 7.04 M), thereby preventing food spoilage caused by Pseudomonas aeruginosa.

HY-103445

SSR69071	Inhibitor	≥98.0%
SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury. SSR69071 displays a higher affinity for human elastase (K_i=0.0168 nM) than for rat (K_i=3 nM), mouse (K_i=1.8 nM), and rabbit (K_i= 58 nM) elastases.

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