2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-172977
    FGA139
    		Inhibitor
    FGA139 is a cysteine proteases inhibitor with IC50 values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research.
    FGA139
  • HY-U00362A
    (Rac)-Neurodegenerative Disorder-Targeting Compound 1
    		Inhibitor
    (Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor (extracted from patent WO2010128102A1, compound 63) .
    (Rac)-Neurodegenerative Disorder-Targeting Compound 1
  • HY-162477
    TS-24
    		Inhibitor 98.96%
    TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis.
    TS-24
  • HY-156655
    Olgotrelvir
    		Inhibitor
    Olgotrelvir (STI-1558) is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir can effectively inhibit both SARS-CoV-2 replication and entry into host cells.
    Olgotrelvir
  • HY-P4565
    Phe-Arg-Arg-Gly
    Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling.
    Phe-Arg-Arg-Gly
  • HY-RS03325
    CTSC Human Pre-designed siRNA Set A
    		Inhibitor

    CTSC Human Pre-designed siRNA Set A contains three designed siRNAs for CTSC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSC Human Pre-designed siRNA Set A
    CTSC Human Pre-designed siRNA Set A
  • HY-108137A
    Z-L(D-Val)G-CHN2
    		Inhibitor 99.35%
    Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
    Z-L(D-Val)G-CHN2
  • HY-119293A
    K777 tosylate
    		Inhibitor
    K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively.
    K777 tosylate
  • HY-RS03342
    Ctsl Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsl Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsl Rat Pre-designed siRNA Set A
    Ctsl Rat Pre-designed siRNA Set A
  • HY-156560
    Z-LVG
    		Inhibitor
    Z-LVG is an irreversible cysteine proteinase inhibitor. Z-LVG is a tripeptide derivative from cystatin C which can inhibit viral replication. Z-LVG can be used for virus diseases research.
    Z-LVG
  • HY-P5975
    Z-Leu-Leu-Leu-fluoromethyl ketone
    		Inhibitor
    Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge.
    Z-Leu-Leu-Leu-fluoromethyl ketone
  • HY-115454
    GB111-NH2
    		Inhibitor
    GB111-NH2 is a cysteine cathepsin inhibitor and can be used in cancer research.
    GB111-NH2
  • HY-153614
    Ac-VLPE-FMK
    		Inhibitor ≥99.0%
    Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness.
    Ac-VLPE-FMK
  • HY-N15154
    Tasiamide B
    		Inhibitor
    Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90.
    Tasiamide B
  • HY-P10061
    Cathepsin K inhibitor 4
    		Inhibitor
    Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC50s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively.
    Cathepsin K inhibitor 4
  • HY-163847
    Anti-osteoporosis agent-9
    		Inhibitor
    Anti-osteoporosis agent-9 (compound 5b) is a N-cyclopropyl-4-((4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)methyl)benzamide derivative that shows anti-osteoclast activity.
    Anti-osteoporosis agent-9
  • HY-RS03338
    Ctsk Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsk Mouse Pre-designed siRNA Set A
    Ctsk Mouse Pre-designed siRNA Set A
  • HY-158022
    CTSL/CAPN1-IN-1
    		Inhibitor
    CTSL/CAPN1-IN-1 (compound 14a) is an oral active CTSL and CAPN1 inhibitor with the IC50  values of 3.34 nM and 375.1 nM for CTSL and CAPN1, respectively. CTSL/CAPN1-IN-1 shows anticoronaviral activity and anti-inflammatory effect.
    CTSL/CAPN1-IN-1
  • HY-152222
    SPR38
    		Inhibitor
    SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a Ki of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with Ki values of 1.92 μM and 11.1 μM, respectively.
    SPR38
  • HY-N12129
    6,6′-Dihydroxythiobinupharidine
    		Inhibitor
    6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively.
    6,6′-Dihydroxythiobinupharidine
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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