2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N6037R
    Gardenin B (Standard)
    		Inhibitor
    Gardenin B (Standard) is the analytical standard of Gardenin B (HY-N6037). This product is intended for research and analytical applications. Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC50: 6.24 μg/mL), and Cathepsin D (IC50: 5.61 μg/mL). Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC50 values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research.
    Gardenin B (Standard)
  • HY-P3153
    Cathepsin K
    Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K is involved in many important processes, including the degradation activity of collagen 1 and elastin in bone resorption.
    Cathepsin K
  • HY-RS03323
    Ctsb Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsb Mouse Pre-designed siRNA Set A
  • HY-RS03333
    Ctse Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctse Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctse gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctse Rat Pre-designed siRNA Set A
  • HY-164634
    CLIK-148
    		Inhibitor
    CLIK-148 is a highly selective, irreversible and orally active cysteine protease inhibitor, primarily targeting Cathepsin L. CLIK-148 effectively inhibits the Cathepsin L-dependent degradation of HMG-CoA reductase in the endoplasmic reticulum (ER) membrane. CLIK-148 inhibits the processing of proCCK by Cathepsin L, thereby reducing the production of CCK8 (HY-P0093). CLIK-148 inhibits the degradation of type I collagen by osteoclasts' secreted Cathepsin L, reducing tumor-induced bone metastasis and malignant hypercalcemia. CLIK-148 can be used for the studies of bone metabolism disorders and regulation of neuropeptide processing.
    CLIK-148
  • HY-D1523
    Z-Arg-Arg-4MβNA triacetate
    Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λex = 355 nm, λem = 430 nm).
    Z-Arg-Arg-4MβNA triacetate
  • HY-P10118
    Cathepsin L-IN-3
    		Inhibitor
    Cathepsin L-IN-3 is a tripeptide-sized cathepsin L inhibitor.
    Cathepsin L-IN-3
  • HY-P11326
    Ac-FR-AFC TFA
    		Substrate
    Ac-FR-AFC TFA is a Cathepsin L fluorogenic substrate (Ex=400 nm, Em=505 nm). Cathepsin L activity in cells lysates is determined by measuring cleavage of Ac-FR-AFC TFA and its cleavage occurs at the FR-AFC amide bond. Ac-FR-AFC TFA can be used for activity assays and mechanistic studies on cathepsin L.
    Ac-FR-AFC TFA
  • HY-P1645A
    Papain (1.5-10 units/mg)
    Papain (1.5-10 units/mg) is a plant proteolytic enzyme in the cysteine protease family, widely used in food, medicine and other fields.
    Papain (1.5-10 units/mg)
  • HY-P5086
    H-Gly-Arg-NH2
    H-Gly-Arg-NH2 is a substrate for the determination of bovine spleen cathepsin C activity.
    H-Gly-Arg-NH2
  • HY-139685
    ABP 25
    		Inhibitor
    ABP 25 is an activity-based probe for cathepsin K imaging with excellent potency and selectivity.
    ABP 25
  • HY-125386
    SQ 32056
    		Inhibitor
    SQ 32056 is a cathepsin E inhibitor. SQ 32056 can block the pressor response to endothelin.
    SQ 32056
  • HY-172977
    FGA139
    		Inhibitor
    FGA139 is a cysteine proteases inhibitor with IC50 values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research.
    FGA139
  • HY-U00362A
    (Rac)-Neurodegenerative Disorder-Targeting Compound 1
    		Inhibitor
    (Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor (extracted from patent WO2010128102A1, compound 63) .
    (Rac)-Neurodegenerative Disorder-Targeting Compound 1
  • HY-156655
    Olgotrelvir
    		Inhibitor
    Olgotrelvir (STI-1558) is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir can effectively inhibit both SARS-CoV-2 replication and entry into host cells.
    Olgotrelvir
  • HY-P4565
    Phe-Arg-Arg-Gly
    Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling.
    Phe-Arg-Arg-Gly
  • HY-108137A
    Z-L(D-Val)G-CHN2
    		Inhibitor 99.35%
    Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
    Z-L(D-Val)G-CHN2
  • HY-119293A
    K777 tosylate
    		Inhibitor
    K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively.
    K777 tosylate
  • HY-RS03342
    Ctsl Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsl Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsl Rat Pre-designed siRNA Set A
  • HY-156560
    Z-LVG
    		Inhibitor
    Z-LVG is an irreversible cysteine proteinase inhibitor. Z-LVG is a tripeptide derivative from cystatin C which can inhibit viral replication. Z-LVG can be used for virus diseases research.
    Z-LVG
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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