2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P4561
    H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH
    H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis.
    H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH
  • HY-168591
    CTSC-IN-1
    		Inhibitor
    CTSC-IN-1 (B22) is a CTSC inhibitor. CTSC-IN-1 inhibits CTSC activity by binding to S2 pocket and S1 site. CTSC-IN-1 can be used in the study inflammatory bowel disease.
    CTSC-IN-1
  • HY-E70197
    Calpain-1 (pig)
    Calpain-1 (pig) (μ-Calpain) is an intracellular Ca2+-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect.
    Calpain-1 (pig)
  • HY-157477
    SARS-CoV-2 3CLpro-IN-22
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-22 (Compound 17) is a cathepsin L (CTSL ) inhibitor with an IC50 value of 32.5 nM. SARS-CoV-2 3CLpro-IN-22 can be used for the study of SARS-CoV-2 virus.
    SARS-CoV-2 3CLpro-IN-22
  • HY-163842
    Cathepsin K inhibitor 7
    		Inhibitor
    Cathepsin K inhibitor 7 (compound 7) is a Cathepsin K inhibitor with the pKi of 7.3 aganist CatK. Cathepsin K inhibitor 7 can be used for study of osteoporosis.
    Cathepsin K inhibitor 7
  • HY-P4494
    Suc-Val-Pro-Phe-pNA
    Suc-Val-Pro-Phe-pNA is a substrate for cathepsin G and can be used to detect the activity of this enzyme.
    Suc-Val-Pro-Phe-pNA
  • HY-RS03327
    Ctsc Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsc Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsc Rat Pre-designed siRNA Set A
  • HY-RS03330
    Ctsd Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsd Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsd Rat Pre-designed siRNA Set A
  • HY-161245
    FGA146
    		Inhibitor
    FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.
    FGA146
  • HY-143714
    Cathepsin K inhibitor 2
    		Inhibitor
    Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78).
    Cathepsin K inhibitor 2
  • HY-P4302
    Z-FK-ck
    		Inhibitor
    Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective gingipain-K-specific inhibitor. Z-FK-ck prolongs plasma thrombin time (TT) in a dose- and time-dependent manner.
    Z-FK-ck
  • HY-P10065
    RKLLW-NH2
    		Inhibitor
    RKLLW-NH2 is a Cathepsin L inhibitor.
    RKLLW-NH2
  • HY-P4532
    Ac-Leu-Val-Lys-Aldehyde
    		Inhibitor
    Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II.
    Ac-Leu-Val-Lys-Aldehyde
  • HY-146581
    Cathepsin C-IN-4
    		Inhibitor
    Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC50 values of 203.4 and 177.6 nM, respectively.
    Cathepsin C-IN-4
  • HY-144812
    Gü1303
    		Inhibitor
    Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen.
    Gü1303
  • HY-161342
    CTSL/CAPN1-IN-2
    		Inhibitor
    CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry.
    CTSL/CAPN1-IN-2
  • HY-123531
    JNJ 10329670
    		Inhibitor
    JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation.
    JNJ 10329670
  • HY-RS03339
    Ctsk Rat Pre-designed siRNA Set A
    		Inhibitor

    Ctsk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsk Rat Pre-designed siRNA Set A
  • HY-151524
    Cathepsin K inhibitor 3
    		Inhibitor
    Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies.
    Cathepsin K inhibitor 3
  • HY-D1634A
    Bz-FVR-AMC TFA
    Bz-FVR-AMC TFA is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM-1s-1. The high concentration of BZ-FVR-AMC inhibits the substrate.
    Bz-FVR-AMC TFA
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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