CaSR Agonist

CaSR Agonists (19):

Cat. No.	Product Name	Effect	Purity

HY-139201A

Poly-D-lysine hydrobromide (MW 70000-150000)	Agonist	99.86%
Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide.

HY-70037

Cinacalcet	Agonist	99.93%
Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

HY-70037A

Cinacalcet hydrochloride	Agonist	99.98%
Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-139201

Poly-D-lysine hydrobromide (MW 30000-70000)	Agonist
Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide.

HY-139201B

Poly-D-lysine hydrobromide (MW 84000)	Agonist
Poly-D-lysine hydrobromide (MW 84000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide.

HY-109106A

Upacicalcet sodium	Agonist	≥98.0%
Upacicalcet sodium is a non-peptide calcimimetic that acts as a CaSR agonist (EC₅₀ = 10.8 nM). Upacicalcet sodium reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet sodium sodium improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet sodium sodium inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet sodium is useful for studying SHPT.

HY-117851

AC-265347	Agonist	99.97%
AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases.

HY-P4376A

Gamma-Glu-Abu TFA	Agonist
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC₅₀ of 0.21 μM in HEK-293 cell.

HY-122819

Calindol hydrochloride	Agonist	99.88%
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM.

HY-107773

GSK3004774	Agonist	98.11%
GSK3004774 is a potent, nonabsorbable agonist of CaSR, with an pEC₅₀ of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC₅₀ of 50 nM for human CaSR.

HY-121584

Lycoperodine-1	Agonist	99.82%
Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca²⁺ sensing receptors (CaSR).

HY-70037AS

Cinacalcet-d₃ hydrochloride	Agonist
Cinacalcet-d₃ (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-109106

Upacicalcet	Agonist
Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist (EC₅₀ = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT.

HY-70037S

Cinacalcet-d₃	Agonist
Cinacalcet-d₃ is the deuterium labeled Cinacalcet. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-P4376

Gamma-Glu-Abu	Agonist
Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC₅₀ of 0.21 μM in HEK-293 cell.

HY-W653978

Cinacalcet-d₄ hydrochloride	Agonist
Cinacalcet-d₄ (AMG-073-d₄) hydrochlorideis deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-70037R

Cinacalcet (Standard)	Agonist
Cinacalcet (Standard) is the analytical standard of Cinacalcet. This product is intended for research and analytical applications. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

HY-70037AR

Cinacalcet hydrochloride (Standard)	Agonist
Cinacalcet (hydrochloride) (Standard) is the analytical standard of Cinacalcet (hydrochloride). This product is intended for research and analytical applications. Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-121584R

Lycoperodine-1 (Standard)	Agonist
Lycoperodine-1 (Standard) is the analytical standard of Lycoperodine-1. This product is intended for research and analytical applications. Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR).

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