2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. BCRP
  5. BCRP Modulator

BCRP Modulator

BCRP Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-101570
    Nedisertib
    		Modulator 99.70%
    Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.