2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W020785R
    Fosthiazate (Standard)
    		Inhibitor
    Fosthiazate (Standard) is the analytical standard of Fosthiazate. This product is intended for research and analytical applications. Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase.
    Fosthiazate (Standard)
  • HY-118275
    FK960
    		Activator
    FK960 is a potential anti-dementia agent that reverses the reduction in cerebral blood flow (rCBF) caused by sensory stimulation by enhancing cholinergic neurotransmission. In macaque experiments, physostigmine (AChE inhibitor; HY-N6608) was able to completely eliminate the rCBF in the sensory cortex increased by vibrotactile stimulation. FK960 (1-1000 μg/kg) can restore the eliminated rCBF response, and the action time can last for 1 hour. However, FK960 cannot restore the rCBF response eliminated by HA-966 (NMDA modulator; HY-100822), indicating that its function is not dependent on non-glutamatergic neurotransmission.
    FK960
  • HY-N4142R
    Cyanidin-3-O-galactoside (chloride) (Standard)
    		Inhibitor
    Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity.
    Cyanidin-3-O-galactoside (chloride) (Standard)
  • HY-18039
    WAY-361789
    		Agonist
    WAY-361789 (SEN15924) is an orally active agonist for α7 nicotinic acetylcholine receptor (α7 nAChR) with an EC50 of 0.18 μM. WAY-361789 improves the cognitive function, exhibits potential in ameliorating Alzheimer’s Disease and schizophrenia.
    WAY-361789
  • HY-W004287
    Methyl tridecanoate
    		Inhibitor 99.20%
    Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE).
    Methyl tridecanoate
  • HY-B1343R
    Pridinol (mesylate) (Standard)
    		Inhibitor
    Pridinol (mesylate) (Standard) is the analytical standard of Pridinol (mesylate). This product is intended for research and analytical applications. Pridinol mesylate is an orally active and potent central anticholinergic agent, and acts as muscle relaxant.
    Pridinol (mesylate) (Standard)
  • HY-N2971
    Buxbodine B
    		Inhibitor
    Buxbodine B is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 50 μM. Buxbodine B can be used in research of Alzheimer's disease.
    Buxbodine B
  • HY-N13924
    Arisugacin D
    		Inhibitor
    Arisugacin D is an acetylcholinesterase (AChE) inhibitor with an IC50 of 3.5 μM.
    Arisugacin D
  • HY-159977
    1,2-Didehydrotanshinone IIA
    		Inhibitor
    1,2-Didehydrotanshinone IIA is a moderate AChE and BChE inhibitor, with an IC50 value of 5.98 μM for BChE.
    1,2-Didehydrotanshinone IIA
  • HY-B1206R
    Neostigmine (methyl sulfate) (Standard)
    		Inhibitor
    Neostigmine (methyl sulfate) (Standard) is the analytical standard of Neostigmine (methyl sulfate). This product is intended for research and analytical applications. 0
    Neostigmine (methyl sulfate) (Standard)
  • HY-169173
    AL284
    		Inhibitor
    AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes.
    AL284
  • HY-119792A
    Neostigmine hydroxide
    		Inhibitor
    Neostigmine hydroxide is a cholinesterase inhibitor and can be used for study of myasthenia gravis.
    Neostigmine hydroxide
  • HY-W540232
    4-Methoxyphenyl isothiocyanate
    		Inhibitor
    4-Methoxyphenyl isothiocyanate (4-Methylphenyl ITC) is an antioxidant, with a IC50 value of 1.25 mM for scavenging DPPH radicals. ORAC testing indicates its antioxidant capacity as 11.7 mM TE (indicating that the antioxidant efficacy of this compound is equivalent to 11.7 mmol of Trolox (HY-101445, a standard antioxidant) under the same conditions), and it extends the oxidation process by approximately 9180 seconds in the Briggs–Rauscher reaction. Additionally, 4-Methoxyphenyl isothiocyanate exhibits moderate cholinesterase inhibitory activity, with an inhibition rate of 30.4% against acetylcholinesterase (AChE) and 17.9% against butyrylcholinesterase (BChE). 4-Methoxyphenyl isothiocyanate holds potential for research in the fields of antioxidation and neurological disorders.
    4-Methoxyphenyl isothiocyanate
  • HY-161029
    T14-A24
    		Inhibitor
    T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (Ki=22 nM, IC50=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile.
    T14-A24
  • HY-163980
    AChE-IN-73
    AChE-IN-73 (compound 6) is an insecticide with higher toxicity than HY-B0815. The LC50 for C. pipiens is 78.0 mg/L. AChE-IN-73 has high affinity for acetylcholinesterase (AChE) and nicotinic acetylcholine receptors (nAChR), with binding energies of -8.11 kcal/mol and -6.27 kcal/mol, respectively. AChE-IN-73 is a potentially potent mosquito inhibitor.
    AChE-IN-73
  • HY-B1881R
    Pirimiphos-methyl (Standard)
    		Inhibitor
    Pirimiphos-methyl (Standard) is the analytical standard of Pirimiphos-methyl. This product is intended for research and analytical applications. Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.
    Pirimiphos-methyl (Standard)
  • HY-N13927
    Arisugacin G
    		Control
    Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE.
    Arisugacin G
  • HY-W782096
    Salvianolic acid H
    		Inhibitor
    Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor.
    Salvianolic acid H
  • HY-118642
    D-Ribose-L-cysteine
    		Inhibitor
    D-Ribose-L-cysteine ​​is an orally active cysteine ​​analog. D-Ribose-L-cysteine ​​improves cellular antioxidant capacity by enhancing intracellular glutathione (GSH) biosynthesis. In addition, D-Ribose-L-cysteine ​​has a memory-enhancing effect and can reverse Scopolamine (HY-N0296)-induced memory impairment by inhibiting oxidative stress and acetylcholinesterase (AChE) activity. D-Ribose-L-cysteine ​​can be used in the study of neurodegenerative and cardiovascular diseases.
    D-Ribose-L-cysteine
  • HY-B0732R
    Itopride (hydrochloride) (Standard)
    		Inhibitor
    Itopride (hydrochloride) (Standard) is the analytical standard of Itopride (hydrochloride). This product is intended for research and analytical applications. Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
    Itopride (hydrochloride) (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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