2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15295
    3-Acetylnerbowdine
    3-Acetylnerbowdine is an alkaloid. 3-Acetylnerbowdine can be obtained from N. bowdenii bulbs. 3-Acetylnerbowdine can be used for the study of acetylcholinesterase activity.
    3-Acetylnerbowdine
  • HY-W715341
    RO-1-5237
    RO-1-5237 is a metabolite of Pyridostigmine Bromide, which is a cholinergic and can be used for myasthenia gravis research.
    RO-1-5237
  • HY-N2425R
    Rhodiosin (Standard)
    		Inhibitor
    Rhodiosin (Standard) is the analytical standard of Rhodiosin. This product is intended for research and analytical applications. Rhodiosin is a double inhibitor of CYP2D6 and AChE, and can be isolated from Rhodiolis rhodiolis root. The IC50 for CYP2D6 is 0.761 μM, and the Ki is 0.769 μM. Rhodiosin has antioxidant and neuroprotective activity and can regulate HIF-1α signaling pathway to protect the central nervous system
    Rhodiosin (Standard)
  • HY-N2912
    Axillaridine A
    		Inhibitor
    Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE.
    Axillaridine A
  • HY-119772
    VU0366369
    		Modulator
    VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases.
    VU0366369
  • HY-N0825R
    Nodakenin (Standard)
    		Inhibitor
    Nodakenin (Standard) is the analytical standard of Nodakenin. This product is intended for research and analytical applications. Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC50 of 84.7 μM.
    Nodakenin (Standard)
  • HY-B2155R
    Acotiamide monohydrochloride trihydrate (Standard)
    		Inhibitor
    Acotiamide (monohydrochloride trihydrate) (Standard) is the analytical standard of Acotiamide (monohydrochloride trihydrate). This product is intended for research and analytical applications. Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
    Acotiamide monohydrochloride trihydrate (Standard)
  • HY-N0702R
    Tenuifolin (Standard)
    		Inhibitor
    Tenuifolin (Standard) is the analytical standard of Tenuifolin. This product is intended for research and analytical applications. Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).
    Tenuifolin (Standard)
  • HY-120479
    Cythioate
    		Inhibitor
    Cythioate is an organophosphorous insecticide and anthelmintic. Cythioate is an acetylcholinesterase inhibitor which interferes with neuromuscular transmission in ectoparastites.
    Cythioate
  • HY-N2192R
    Swertianolin (Standard)
    		Inhibitor
    Swertianolin (Standard) is the analytical standard of Swertianolin. This product is intended for research and analytical applications. Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity.
    Swertianolin (Standard)
  • HY-B1881S
    Pirimiphos-methyl-d6
    		Inhibitor
    Pirimiphos-methyl-d6 is the deuterium labeled Pirimiphos-methyl (HY-B1881). Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.
    Pirimiphos-methyl-d<sub>6</sub>
  • HY-129468
    Pirimiphos ethyl
    		Inhibitor
    Pirimiphos ethyl is a kind of organophosphorus pesticide that commonly employes for the protection of crops including vegetables, bananas, turf and mushrooms through the inhibition of acetylcholinesterase activity.
    Pirimiphos ethyl
  • HY-B1863R
    Iprobenfos (Standard)
    		Inhibitor
    Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
    Iprobenfos (Standard)
  • HY-76299S2
    Galanthamine-d3 hydrochloride
    		Inhibitor
    Galanthamine-d3 (Galantamine-d3) hydrochloride is deuterium-labeled Galanthamine (HY-76299).
    Galanthamine-d<sub>3</sub> hydrochloride
  • HY-B1542
    Benactyzine
    		Inhibitor
    Benactyzine is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine is an anticholinergic drug. Benactyzine has the potential for organophosphate poisoning research.
    Benactyzine
  • HY-N0740R
    Jatrorrhizine chloride (Standard)
    		Inhibitor
    Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.
    Jatrorrhizine chloride (Standard)
  • HY-N14533
    Quinolactacin A2
    		Inhibitor
    Quinolactacin A2 inhibits acetylcholinesterase and TNF production.
    Quinolactacin A2
  • HY-165600A
    Trimedoxime
    		Activator
    Trimedoxime (TMB-4) is a potent reactivator of AChE. Trimedoxime shows potency in inducing oxidative stress, with the IC50 of 22 mM.
    Trimedoxime
  • HY-N13902
    Arisugacin B
    		Inhibitor
    Arisugacin B is a potent, orally active and selective acetylcholinesterase (AChE) inhibitor.
    Arisugacin B
  • HY-17368S1
    (Rac)-Rivastigmine-d6
    		Inhibitor
    (Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    (Rac)-Rivastigmine-d<sub>6</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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