2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine chloride dihydrochloride

S-Adenosyl-L-methionine chloride dihydrochloride  (Synonyms: S-Adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride)

Cat. No.: HY-14614A Purity: ≥75.0%
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COA
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S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine chloride dihydrochloride Chemical Structure

S-Adenosyl-L-methionine chloride dihydrochloride Chemical Structure

CAS No. : 86867-01-8

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Based on 5 publication(s) in Google Scholar

Other Forms of S-Adenosyl-L-methionine chloride dihydrochloride:

S-Adenosyl-L-methionine chloride dihydrochloride Related Antibodies

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Description

S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

In Vitro

S-Adenosyl-L-methionine (300 µM, 24 or 48 h) chloride dihydrochloride induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells[4].
S-Adenosyl-L-methionine (300 µM, 24 h) chloride dihydrochloride decreases the migration of the Cal-33 and JHU-SCC-011 cells[4].
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) chloride dihydrochloride protects the anticancer effect of 5‑FU by regulating the expression of DNMTs[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-Adenosyl-L-methionine chloride dihydrochloride Related Antibodies

Apoptosis Analysis[4]

Cell Line: Cal-33 and JHU-SCC-011 cells
Concentration: 300 µM
Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

Western Blot Analysis[4]

Cell Line: Cal-33 and JHU-SCC-011 cells
Concentration: 300 µM
Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
In Vivo

S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) chloride dihydrochloride prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice[6].
S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) chloride dihydrochloride shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Valproic acid treated young mice[6]
Dosage: 30 mg/kg
Administration: p.o., for 3 days
Result: Alleviated most ASD like neurobehavioral symptoms.
Normalized the redox potential in the prefrontal cortex.
Molecular Weight

507.82

Formula

C15H25Cl3N6O5S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1C[S+](CC[C@H](N)C(O)=O)C.[H]Cl.[H]Cl.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (98.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9692 mL 9.8460 mL 19.6920 mL
5 mM 0.3938 mL 1.9692 mL 3.9384 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥75.0%

SDS (393 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.9692 mL 9.8460 mL 19.6920 mL 49.2300 mL
5 mM 0.3938 mL 1.9692 mL 3.9384 mL 9.8460 mL
10 mM 0.1969 mL 0.9846 mL 1.9692 mL 4.9230 mL
15 mM 0.1313 mL 0.6564 mL 1.3128 mL 3.2820 mL
20 mM 0.0985 mL 0.4923 mL 0.9846 mL 2.4615 mL
25 mM 0.0788 mL 0.3938 mL 0.7877 mL 1.9692 mL
30 mM 0.0656 mL 0.3282 mL 0.6564 mL 1.6410 mL
40 mM 0.0492 mL 0.2462 mL 0.4923 mL 1.2308 mL
50 mM 0.0394 mL 0.1969 mL 0.3938 mL 0.9846 mL
60 mM 0.0328 mL 0.1641 mL 0.3282 mL 0.8205 mL
80 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6154 mL
DMSO 100 mM 0.0197 mL 0.0985 mL 0.1969 mL 0.4923 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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S-Adenosyl-L-methionine chloride dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Adenosyl-L-methionine chloride86867-01-8S-Adenosyl methionine chlorideAdemetionine chlorideAdoMet chlorideEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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