2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N3815
    ent-16-Kaurene-3b,15b,18-triol 921211-29-2 98%
    ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen.
    ent-16-Kaurene-3b,15b,18-triol
  • HY-N3831
    Epimedokoreanin B 161068-53-7 98%
    Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.
    Epimedokoreanin B
  • HY-N3846
    Ergosterol peroxide glucoside 140447-22-9 98%
    Ergosterol peroxide glucoside is an Ergosterol derivative.
    Ergosterol peroxide glucoside
  • HY-N3848
    Ermanin 20869-95-8 98%
    Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.
    Ermanin
  • HY-N3858
    Erythristemine 28619-41-2 98%
    Erythristemine is an alkaloid that can be isolated from Erythrina lysistemon. Erythristemine has weak DPPH radical scavenging properties.
    Erythristemine
  • HY-N3866
    Esculentic acid 103974-74-9 98%
    Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta.
    Esculentic acid
  • HY-N3891
    Fargesone A 116424-69-2 98%
    Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity.
    Fargesone A
  • HY-N4022
    Hyuganin D 77331-76-1 98%
    Hyuganin D (Isobocconin) is a Coumarin (HY-N0709) constituent that substantially inhibits LPS (HY-D1056)-induced NO production in mouse peritoneal macrophages.
    Hyuganin D
  • HY-N4024
    Hyptadienic acid 128397-09-1
    Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID50 value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation.
    Hyptadienic acid
  • HY-N4037
    Homopterocarpin 606-91-7 98%
    Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.
    Homopterocarpin
  • HY-N4061
    Hedycoronen A 1383441-73-3 98%
    Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC50s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium.
    Hedycoronen A
  • HY-N4063
    Hedragonic acid 466-02-4 98%
    Hedragonic acid is an oleane-type triterpenoid compound, which can be isolated from the stems and roots of the southern snake vine. Hedragonic acid is a ligand and agonist for FXR. Hedragonic acid protected mice from liver damage caused by acetaminophen overdose and reduced liver inflammation.
    Hedragonic acid
  • HY-N4080
    Cyclobuxine D 2241-90-9 98%
    Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum.
    Cyclobuxine D
  • HY-N4125
    Dehydroeburicoic acid monoacetate 77035-42-8
    Dehydroeburicoic acid monoacetate (Compound 18) is a lanostane triterpenoid isolated from Wolfiporia cocos.
    Dehydroeburicoic acid monoacetate
  • HY-N4128
    4''-methyloxy-Daidzin 1195968-02-5 98%
    4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities.
    4''-methyloxy-Daidzin
  • HY-N4129
    4''-methyloxy-Genistin 950910-16-4 98%
    4''-methyloxy-Genistin, an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities.
    4''-methyloxy-Genistin
  • HY-N4147
    Eleutheroside D 79484-75-6 98%
    Eleutheroside D is an active lignan isolated from the root of Eleutherococcus senticosus, has anti-inflammatory and hypoglycemic activities. Eleutheroside D is an optical isomer of Eleutheroside E (HY-N0272).
    Eleutheroside D
  • HY-N4190
    Britannilactone diacetate 1286694-67-4 98%
    Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.
    Britannilactone diacetate
  • HY-N4215
    11(α)-Methoxysaikosaponin F 104109-37-7 ≥99.0%
    11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6). Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity.
    11(α)-Methoxysaikosaponin F
  • HY-N4230
    Clematomandshurica saponin B 916649-91-7 98%
    Clematomandshurica saponins B shows significant inhibitory activity on cyclooxygenase-2 (IC50=2.58 mM).
    Clematomandshurica saponin B
Cat. No. Product Name / Synonyms Application Reactivity