2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-171181
    ZINC20451377 2306303-35-3 98%
    ZINC20451377 is a small molecule targeting hepatitis B (HBV) surface antigen (HBsAg) and can effectively inhibit wild-type hepatitis B and tenofovir (HY-13910)-resistant hepatitis B.
    ZINC20451377
  • HY-171189
    C-467929 351891-58-2 98%
    C-467929 is an Nsp15 endoribonuclease inhibitor with an IC50 of 8 μM. C-467929 binds to the SARS-CoV Nsp15 protein and can be utilized in infection research.
    C-467929
  • HY-171190
    ELQ-316 1354745-69-9 98%
    ELQ-316 is an endochinlike quinolone compound and an anti-parasite agent. ELQ-316 demonstrates a great efficacy against acute and chronic experimental toxoplasmosis.
    ELQ-316
  • HY-171208
    In vivo Stat1 Mouse Pre-designed siRNA-1 98%
    In vivo Stat1 Mouse Pre-designed siRNA-1 is a siRNA product designed for the Stat1 (Mouse) gene and can be used for in vivo experiments in mice.
    In vivo Stat1 Mouse Pre-designed siRNA-1
  • HY-171209
    In vivo Stat1 Mouse Pre-designed siRNA-2 98%
    In vivo Stat1 Mouse Pre-designed siRNA-2 is a siRNA product designed for the Stat1 (Mouse) gene and can be used for in vivo experiments in mice.
    In vivo Stat1 Mouse Pre-designed siRNA-2
  • HY-171210
    In vivo Stat1 Mouse Pre-designed siRNA-3 98%
    In vivo Stat1 Mouse Pre-designed siRNA-3 is a siRNA product designed for the Stat1 (Mouse) gene and can be used for in vivo experiments in mice.
    In vivo Stat1 Mouse Pre-designed siRNA-3
  • HY-171233
    MRSA antibiotic 2 667410-02-8 98%
    MRSA antibiotic 2 (compound 2) shows MIC of 2 μg/mL for S. aureus (MRSA). MRSA antibiotic 2 selectively target Gram-positive bacteria over Gram-negative bacteria and human cells.
    MRSA antibiotic 2
  • HY-171362
    PSI-7410 1015073-44-5 98%
    PSI-7410 is the metabolite of PSI-7851 (HY-14308). PSI-7851 is an inhibitor for HCV nonstructural protein 5B (NS5B) and exhibits antiviral activity.
    PSI-7410
  • HY-171457
    WR-27653 6042-36-0 98%
    WR-27653 (RC-12) is a derivative of Catechol with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) model. WR-27653 has antimalarial activity.
    WR-27653
  • HY-171587
    3′-Deoxy CTP 69383-05-7 98%
    3′-Deoxy CTP is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs.
    3′-Deoxy CTP
  • HY-171591
    SIK2-IN-4 2810810-00-3 98%
    SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC50: 0.11 µM), IL-12/23 p40 (IC50: 0.25 µM), and IL-23 (IC50: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases.
    SIK2-IN-4
  • HY-171795
    Isolubimin 60077-68-1 98%
    Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.
    Isolubimin
  • HY-171832
    5'-Amino-5'-deoxyuridine 34718-92-8
    5'-Amino-5'-deoxyuridine is a nucleoside analog that can be used in nucleic acid synthesis.
    5'-Amino-5'-deoxyuridine
  • HY-172006
    Probetaenone I 115473-44-4 98%
    Probetaenone I is an intermediate in the biosynthesis of the phytotoxin betaenone B from P. betae.
    Probetaenone I
  • HY-172007
    Acremine F 863480-61-9 98%
    Acremine F is a fungal metabolite that has been found in Acremonium.
    Acremine F
  • HY-172023
    apo-Enterobactin 30414-16-5 98%
    apo-Enterobactin is a derivative of Enterobactin (HY-128525). Enterobactin is a bacterial siderophore that promotes iron absorption.
    apo-Enterobactin
  • HY-172027
    Remdesivir methylpropyl ester analog 3047145-80-9 98%
    Remdesivir methylpropyl ester analog (GS-5734 methylpropyl ester analog) is a derivative of Remdesivir (HY-104077). Remdesivir is a nucleoside analogue with effective antiviral activity.
    Remdesivir methylpropyl ester analog
  • HY-172109
    DNA Gyrase-IN-15 98%
    DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis.
    DNA Gyrase-IN-15
  • HY-172207
    POPTc80-IN-1 98%
    POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC50 of 0.23 μM and a Ki of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC50 of 46.71 μM.
    POPTc80-IN-1
  • HY-172216
    EV-A71-IN-3 98%
    EV-A71-IN-3 (Compound IRE-03-3) is the inhibitor for Enterovirus A71 EV-A71 that targets internal ribosomal entry site (IRES) of EV-A71, inhibits IRES-mediated translation, and inhibits the viral proliferation with an EC50 of 11.96 μM.
    EV-A71-IN-3
Cat. No. Product Name / Synonyms Application Reactivity