2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 6-Methyluridine

6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.

For research use only. We do not sell to patients.

6-Methyluridine Chemical Structure

6-Methyluridine Chemical Structure

CAS No. : 16710-13-7

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Based on 1 publication(s) in Google Scholar

6-Methyluridine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents[1].

Cellular Effect
Cell Line Type Value Description References
COLO 205 IC50
> 50 μM
Compound: 18
Antitumor activity against human COLO205 cells after 3 days by WST1 assay
Antitumor activity against human COLO205 cells after 3 days by WST1 assay
[PMID: 19260677]
MCF7 IC50
> 50 μM
Compound: 18
Antitumor activity against human MCF7 cells after 3 days by WST1 assay
Antitumor activity against human MCF7 cells after 3 days by WST1 assay
[PMID: 19260677]
MDA-MB-468 IC50
> 50 μM
Compound: 18
Antitumor activity against human MDA468 cells after 3 days by WST1 assay
Antitumor activity against human MDA468 cells after 3 days by WST1 assay
[PMID: 19260677]
OCI-AML2 IC50
> 50 μM
Compound: 18
Antitumor activity against human OCI-AML2 cells after 3 days by WST1 assay
Antitumor activity against human OCI-AML2 cells after 3 days by WST1 assay
[PMID: 19260677]
OCI-Ly7 IC50
> 50 μM
Compound: 18
Antitumor activity against human OCI-LY7 cells after 3 days by WST1 assay
Antitumor activity against human OCI-LY7 cells after 3 days by WST1 assay
[PMID: 19260677]
OVCAR-4 IC50
> 50 μM
Compound: 18
Antitumor activity against human OVCAR4 cells after 3 days by WST1 assay
Antitumor activity against human OVCAR4 cells after 3 days by WST1 assay
[PMID: 19260677]
Molecular Weight

258.23

Formula

C10H14N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C(C)=C2)C(NC2=O)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (193.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8725 mL 19.3626 mL 38.7252 mL
5 mM 0.7745 mL 3.8725 mL 7.7450 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8725 mL 19.3626 mL 38.7252 mL 96.8129 mL
5 mM 0.7745 mL 3.8725 mL 7.7450 mL 19.3626 mL
10 mM 0.3873 mL 1.9363 mL 3.8725 mL 9.6813 mL
15 mM 0.2582 mL 1.2908 mL 2.5817 mL 6.4542 mL
20 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8406 mL
25 mM 0.1549 mL 0.7745 mL 1.5490 mL 3.8725 mL
30 mM 0.1291 mL 0.6454 mL 1.2908 mL 3.2271 mL
40 mM 0.0968 mL 0.4841 mL 0.9681 mL 2.4203 mL
50 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9363 mL
60 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6135 mL
80 mM 0.0484 mL 0.2420 mL 0.4841 mL 1.2102 mL
100 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.9681 mL
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6-Methyluridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Methyluridine16710-13-7Nucleoside Antimetabolite/AnaloganticonvulsantanxiolyticantiepilepticantihypertensiveInhibitorinhibitorinhibit

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