2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. β-Nicotinamide mononucleotide, reduced form disodium

β-Nicotinamide mononucleotide, reduced form disodium  (Synonyms: NMNH disodium)

Cat. No.: HY-W615108B Purity: 99.55%
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COA
Handling Instructions Technical Support

β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is an orally active reduced version of β-Nicotinamide mononucleotide (HY-F0004). β-Nicotinamide mononucleotide, reduced form disodium can significantly increase the levels of NAD+ and NADH, inhibit glycolysis, the tricarboxylic acid cycle, and cell growth, with its effects being dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT).

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β-Nicotinamide mononucleotide, reduced form disodium Chemical Structure

β-Nicotinamide mononucleotide, reduced form disodium Chemical Structure

CAS No. : 108347-85-9

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Based on 1 publication(s) in Google Scholar

β-Nicotinamide mononucleotide, reduced form disodium Related Antibodies

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Description

β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is an orally active reduced version of β-Nicotinamide mononucleotide (HY-F0004). β-Nicotinamide mononucleotide, reduced form disodium can significantly increase the levels of NAD+ and NADH, inhibit glycolysis, the tricarboxylic acid cycle, and cell growth, with its effects being dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT)[1][2].

In Vitro

β-Nicotinamide mononucleotide, reduced form (100 μM; 12 h) disodium can significantly increase the level of NAD+ in HepG2 cells and reduce the levels of glycolysis and TCA cycle intermediates[1].
β-Nicotinamide mononucleotide, reduced form (250-1000 μM; 12-72 h) disodium can inhibit the growth of HepG2 cells and induce cell cycle arrest[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Nicotinamide mononucleotide, reduced form disodium Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 10, 50, 100, 250 and 500 μM
Incubation Time: 72 h
Result: Inhibited HepG2 cell growth at concentrations higher than 250 μM.
In Vivo

β-Nicotinamide mononucleotide, reduced form (340 mg/kg; intraperitoneal injection/oral gavage; single dose) disodium can increase the NAD+ level in the liver of male mice[1].
β-Nicotinamide mononucleotide, reduced form (250 mg/kg; intraperitoneal injection; single dose) disodium can increase the NAD+ levels by 2-5 times in tissues such as the liver, kidney, brain, muscle, and whole blood of C57BL/6J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

380.20

Formula

C11H15N2Na2O8P
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=C(CC=C2)C(N)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (263.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6302 mL 13.1510 mL 26.3019 mL
5 mM 0.5260 mL 2.6302 mL 5.2604 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.55%

SDS (393 KB)

COA (254 KB) HNMR (269 KB) CNMR (229 KB) RP-HPLC (251 KB) MS (72 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6302 mL 13.1510 mL 26.3019 mL 65.7549 mL
5 mM 0.5260 mL 2.6302 mL 5.2604 mL 13.1510 mL
10 mM 0.2630 mL 1.3151 mL 2.6302 mL 6.5755 mL
15 mM 0.1753 mL 0.8767 mL 1.7535 mL 4.3837 mL
20 mM 0.1315 mL 0.6575 mL 1.3151 mL 3.2877 mL
25 mM 0.1052 mL 0.5260 mL 1.0521 mL 2.6302 mL
30 mM 0.0877 mL 0.4384 mL 0.8767 mL 2.1918 mL
40 mM 0.0658 mL 0.3288 mL 0.6575 mL 1.6439 mL
50 mM 0.0526 mL 0.2630 mL 0.5260 mL 1.3151 mL
60 mM 0.0438 mL 0.2192 mL 0.4384 mL 1.0959 mL
80 mM 0.0329 mL 0.1644 mL 0.3288 mL 0.8219 mL
100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6575 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Nicotinamide mononucleotide, reduced form disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Nicotinamide mononucleotide, reduced form disodium108347-85-9NMNH disodiumEndogenous MetabolitemiceHepG2NAD+NADHInhibitorinhibitorinhibit

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