2. Cytoskeleton
  3. Integrin
  4. αVβ8-IN-1

αVβ8-IN-1 is a αVβ8 integrin inhibitor. αVβ8-IN-1 has been shown to inhibit the growth of tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 can be used in research related to idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and tumors.

For research use only. We do not sell to patients.

αVβ8-IN-1

αVβ8-IN-1 Chemical Structure

CAS No. : 3048440-55-4

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Based on 1 publication(s) in Google Scholar

αVβ8-IN-1 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

αVβ8-IN-1 is a αVβ8 integrin inhibitor. αVβ8-IN-1 has been shown to inhibit the growth of tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 can be used in research related to idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and tumors[1].
Molecular Weight

502.01

Formula

C25H32ClN5O4
CAS No.
Appearance

Solid

SMILES

OC([C@H](CCOCCCCC(N1)=CC=C2C1=NCCC2)NC(C3(C4=C(Cl)N=CN=C4C)CC3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (249.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9920 mL 9.9600 mL 19.9199 mL
5 mM 0.3984 mL 1.9920 mL 3.9840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9920 mL 9.9600 mL 19.9199 mL 49.7998 mL
5 mM 0.3984 mL 1.9920 mL 3.9840 mL 9.9600 mL
10 mM 0.1992 mL 0.9960 mL 1.9920 mL 4.9800 mL
15 mM 0.1328 mL 0.6640 mL 1.3280 mL 3.3200 mL
20 mM 0.0996 mL 0.4980 mL 0.9960 mL 2.4900 mL
25 mM 0.0797 mL 0.3984 mL 0.7968 mL 1.9920 mL
30 mM 0.0664 mL 0.3320 mL 0.6640 mL 1.6600 mL
40 mM 0.0498 mL 0.2490 mL 0.4980 mL 1.2450 mL
50 mM 0.0398 mL 0.1992 mL 0.3984 mL 0.9960 mL
60 mM 0.0332 mL 0.1660 mL 0.3320 mL 0.8300 mL
80 mM 0.0249 mL 0.1245 mL 0.2490 mL 0.6225 mL
100 mM 0.0199 mL 0.0996 mL 0.1992 mL 0.4980 mL
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αVβ8-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

αVβ8-IN-13048440-55-4IntegrinEMT6CT26KPCTKCC-10NSIPtumorInhibitorinhibitorinhibit

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