α-Zearalenol-d₄

Cat. No.: HY-N6710S: Data Sheet Handling Instructions
FAQs
Technical Support

α-Zearalenol-d4 is a deuterated labeled α-Zearalenol. α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects.

For research use only. We do not sell to patients.

α-Zearalenol-d<sub>4</sub> Chemical Structure

α-Zearalenol-d₄ Chemical Structure

CAS No. : 1778734-73-8

Size	Price	Stock	Quantity
1 mg		Get quote	Estimated Time of Arrival: December 31
500 μg		In-stock	Estimated Time of Arrival: December 31

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of α-Zearalenol-d₄:

α-Zearalenol In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

α-Zearalenol-d4 is a deuterated labeled α-Zearalenol^[1]. α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects^[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells with an IC₅₀ of 12.5 μM^[2].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells^[3].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells^[3].
α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.40

Formula

C₁₈H₂₀D₄O₅

CAS No.

1778734-73-8

Unlabeled CAS

36455-72-8

SMILES

OC1=C2C(/C=C/CCC([2H])([2H])[C@H](C([2H])([2H])CC[C@@H](OC2=O)C)O)=CC(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (308.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0826 mL	15.4131 mL	30.8261 mL
5 mM	0.6165 mL	3.0826 mL	6.1652 mL
10 mM	0.3083 mL	1.5413 mL	3.0826 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. .Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242. [Content Brief]

[3]. Marin DE, et al. Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites. Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392(8):937-947. [Content Brief]

[4]. Nittoli AC, et al. Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach. Metabolomics. 2018 Feb 14;14(3):33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0826 mL	15.4131 mL	30.8261 mL	77.0654 mL
	5 mM	0.6165 mL	3.0826 mL	6.1652 mL	15.4131 mL
	10 mM	0.3083 mL	1.5413 mL	3.0826 mL	7.7065 mL
	15 mM	0.2055 mL	1.0275 mL	2.0551 mL	5.1377 mL
	20 mM	0.1541 mL	0.7707 mL	1.5413 mL	3.8533 mL
	25 mM	0.1233 mL	0.6165 mL	1.2330 mL	3.0826 mL
	30 mM	0.1028 mL	0.5138 mL	1.0275 mL	2.5688 mL
	40 mM	0.0771 mL	0.3853 mL	0.7707 mL	1.9266 mL
	50 mM	0.0617 mL	0.3083 mL	0.6165 mL	1.5413 mL
	60 mM	0.0514 mL	0.2569 mL	0.5138 mL	1.2844 mL
	80 mM	0.0385 mL	0.1927 mL	0.3853 mL	0.9633 mL
	100 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.7707 mL