2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. α-Androstenol

α-Androstenol  (Synonyms: 5α-Androst-16-en-3α-ol)

Cat. No.: HY-W677042 Purity: 97.03%
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α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice.

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α-Androstenol

α-Androstenol Chemical Structure

CAS No. : 1153-51-1

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Based on 1 publication(s) in Google Scholar

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Description

α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice[1][2][3].

Molecular Weight

274.44

Formula

C19H30O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]12CC=C[C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (15.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6438 mL 18.2189 mL 36.4378 mL
5 mM 0.7288 mL 3.6438 mL 7.2876 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6438 mL 18.2189 mL 36.4378 mL 91.0946 mL
5 mM 0.7288 mL 3.6438 mL 7.2876 mL 18.2189 mL
10 mM 0.3644 mL 1.8219 mL 3.6438 mL 9.1095 mL
15 mM 0.2429 mL 1.2146 mL 2.4292 mL 6.0730 mL
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α-Androstenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Androstenol1153-51-15α-Androst-16-en-3α-olGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorsteroid pheromoneboar testeshuman male axillary sweatmouse cerebellar granule cellsseizuresanxiolytic-like activityInhibitorinhibitorinhibit

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